CAJ | 학술논문

目的探讨近年来大黄甘草汤的研究及应用概况，为扩大其使用和临床治疗范围提供一定参考。方法从大黄甘草汤的化学成分、药理研究、临床应用和应用展望4个方面展开，系统阐述其研究及应用概况。结果现有研究主要考察大黄甘草汤中蒽醌类化合物和甘草酸类成分在单煎液、合煎液中的含量差异以及不同煎煮方法、煎煮时间对其含量的影响。大黄甘草汤对改善重症急性胰腺炎（SAP）并发肝损伤大鼠的胰腺及肝脏组织损伤、抑制平滑肌和解痉等均有一定作用。大黄甘草汤临床可以治疗呕吐、便秘、胰腺炎、胆石症等。结论大黄甘草汤在胃肠功能紊乱方面有着广泛应用。纳米乳是应用前景广阔的纳米药物载体之一，大黄甘草汤及活性成分纳米乳有望对大肠癌的临床治疗提供新的思路和方法。
목적탐토근년래대황감초탕적연구급응용개황，위확대기사용화림상치료범위제공일정삼고。방법종대황감초탕적화학성분、약리연구、림상응용화응용전망4개방면전개，계통천술기연구급응용개황。결과현유연구주요고찰대황감초탕중은곤류화합물화감초산류성분재단전액、합전액중적함량차이이급불동전자방법、전자시간대기함량적영향。대황감초탕대개선중증급성이선염（SAP）병발간손상대서적이선급간장조직손상、억제평활기화해경등균유일정작용。대황감초탕림상가이치료구토、편비、이선염、담석증등。결론대황감초탕재위장공능문란방면유착엄범응용。납미유시응용전경엄활적납미약물재체지일，대황감초탕급활성성분납미유유망대대장암적림상치료제공신적사로화방법。
Objective To investigate the research and application profiles of rhubarb licorice soup in recent years and provide a reference to expand the scope of its use and clinical treatment. Methods From four aspects of rhubarb and licorice soup, the chemical composition, pharmacological research, clinical applications and application prospect, we systematically elaborated its research and application profiles. Results The present studies examined different contents of anthraquinone compounds and licorice acids of rhubarb and licorice soup in a single decoction and combined decoction, and influence of different boiling methods, boiling time on their contents. Rhubarb and licorice soup have some effect on improving severe acute pancreatitis (SAP) complicated by liver pancreas and liver damage in rats tissue damage, inhibition of smooth muscle spasm, and so on. rhubarb decoction can treat vomiting, constipation, pancreatitis, cholelithiasis in clinical. Conclusion Rhubarb and licorice soup has a wide application in gastrointestinal dysfunction. Nanoemulsion is a promising nano-drug carriers, there is no report about rhubarb and licorice decoction and its active ingredient nanoemulsion and its treatment on colorectal cancer, and it is expected to provide new ideas and methods for the treatment of colorectal cancer clinically.