CAJ | 학술논문

目的：探讨阿仑膦酸钠增加绝经后妇女骨密度，降低骨折的疗效。方法陕西省人民医院老年病门诊及住院患者，用简单随机化方法分为研究组和对照组。研究疗程为12个月，在治疗前、6个月末和12个月末对阿仑膦酸钠的疗效进行评估。结果本研究共入组60例（碳酸钙组：30例、阿仑膦酸钠组：30例），在6个月末和12个月末：髋骨的骨密度阿仑膦酸钠组较碳酸钙组明显增高，差异有统计学意义（ P＜0．05）。骨钙素测定阿仑膦酸钠组较碳酸钙组明显降低，差异有统计学意义（ P＜0．05）。尿Ⅰ型胶原氨基末端肽/肌酐（NTX/Cr）阿仑膦酸钠组较碳酸钙组明显降低（P＜0．01）。再发骨折率阿仑膦酸钠组（3．33％）较碳酸钙组（16．67％）明显下降（P＜0．01）。结论与碳酸钙对比，阿仑膦酸钠降低骨转换，增加绝经后骨质疏松症患者的骨密度，减少骨折发生率。
목적：탐토아륜련산납증가절경후부녀골밀도，강저골절적료효。방법합서성인민의원노년병문진급주원환자，용간단수궤화방법분위연구조화대조조。연구료정위12개월，재치료전、6개월말화12개월말대아륜련산납적료효진행평고。결과본연구공입조60례（탄산개조：30례、아륜련산납조：30례），재6개월말화12개월말：관골적골밀도아륜련산납조교탄산개조명현증고，차이유통계학의의（ P＜0．05）。골개소측정아륜련산납조교탄산개조명현강저，차이유통계학의의（ P＜0．05）。뇨Ⅰ형효원안기말단태/기항（NTX/Cr）아륜련산납조교탄산개조명현강저（P＜0．01）。재발골절솔아륜련산납조（3．33％）교탄산개조（16．67％）명현하강（P＜0．01）。결론여탄산개대비，아륜련산납강저골전환，증가절경후골질소송증환자적골밀도，감소골절발생솔。
Objective To study the change of bone mineral density ( BMD) in postmenopausal osteoporosis after alendronate treatment .Methods Patient selected from the Geriatric Departement of Shanxi Provincial People's Hospital with simple randomized method , the research object will be divided into experimental group and control group.The whole treatment lasted for 12 months,before and during the treatment ,at end of 6 and 12 months of alendr-onate did curative effect evaluation .Results Sixty cases were analyzed ( calcium carbonate group 30 casesand alen-dronate sodium group 30 cases).After treatment,at the end of 6 and 12 months:hip bone mineral density of alendr-onate group was significantly higher than that of calcium carbonate group ,and the results have significant difference (P<0.05).Osteocalcin in alendronate group reduced significantly than that in calcium carbonate group (P<0.05). Type I collagen amino terminal peptide ( NTX/Cr) in alendronate group also reduced significantly than that in calci-um carbonate group (P<0.01).Fracture rate of alendronate group was 3.33%,while calcium carbonate group was 16.67%.Two groups were dramatically different ,P<0.001.Conclusion Compared with calcium carbonate ,alendr-onate could reduce bone conversion ,increase the bone mineral density ,and reduce the incidence of fracture in postm-enopausal osteoporosis .