CAJ | 학술논문

目的：探讨唑来膦酸单药治疗肺癌合并骨转移的临床疗效。方法将56例肺癌合并骨转移的患者随机分为两组，分别使用唑来膦酸和帕米膦酸单药静脉滴注治疗，治疗3个月后，比较两组患者的疼痛治疗效果、生活质量评分（QOL）、一般状况评分（KPS）及不良反应的发生情况。结果两组的疼痛治疗有效率、不良反应的发生率比较，差异均无统计学意义（P>0.05）。两组患者治疗后的QOL和KPS评分与治疗前比较，差异有统计学意义（P<0.05），但两组之间QOL和KPS评分比较，差异无统计学意义（P<0.05）。结论唑来膦酸可有效缓解肺癌并骨转移患者的疼痛，综合疗效与帕米膦酸相当。
목적：탐토서래련산단약치료폐암합병골전이적림상료효。방법장56례폐암합병골전이적환자수궤분위량조，분별사용서래련산화파미련산단약정맥적주치료，치료3개월후，비교량조환자적동통치료효과、생활질량평분（QOL）、일반상황평분（KPS）급불량반응적발생정황。결과량조적동통치료유효솔、불량반응적발생솔비교，차이균무통계학의의（P>0.05）。량조환자치료후적QOL화KPS평분여치료전비교，차이유통계학의의（P<0.05），단량조지간QOL화KPS평분비교，차이무통계학의의（P<0.05）。결론서래련산가유효완해폐암병골전이환자적동통，종합료효여파미련산상당。
Objective To investigate the clinical effects of zoledronic acid monotherapy on the lung cancer combined with bone metastasis. Methods Fifty-six cases of lung cancer patients with bone metastasis were randomly divided into two groups. The experimental group was treated by zoledronic acid and the control group by pamidronate infusion therapy. The efficiency of pain treatment, quality of life( QOL), Karnofsky performance score (KPS) and the incidence of adverse reactions were compared between the two groups. Results No significant differences were found in the efficiency of pain treatment and incidence rate of adverse reactions between the two groups (P>0.05). After treatment, the QOL and KPS of two groups were significantly dif-ferent from those before treatment (P<0.05), but had no significant differences between the two groups (P>0.05). Conclusion Zoledronic acid monotherapy could effectively alleviate pains of lung cancer patients with bone metastasis. It had equal analgesia effect as pamidronate in the treatment.