CAJ | 학술논문

目的：通过测定颈椎病中疼痛患者血清炎性细胞因子的含量及其疼痛的关系，对其病变深入研究。方法选取2012-01-2012-12我院门诊和住院的颈椎病中疼痛患者48例为试验组。颈椎病根据临床症状结合影像学检查确诊。选择成年健康体检者40例为对照组；采用放免法测定血清中白细胞介素6、肿瘤坏死因子α的含量，应用目测类比评分法测定患者疼痛程度。结果试验组血清白细胞介素6、肿瘤坏死因子α、白细胞介素1β含量显著高于对照组（P<0．05），且试验组中重度疼痛组上述血清细胞因子含量亦显著高于轻度疼痛组（P<0．05）。结论颈椎病中疼痛患者血清白细胞介素6、肿瘤坏死因子α、白细胞介素1β明显升高是导致疼痛的因素。
목적：통과측정경추병중동통환자혈청염성세포인자적함량급기동통적관계，대기병변심입연구。방법선취2012-01-2012-12아원문진화주원적경추병중동통환자48례위시험조。경추병근거림상증상결합영상학검사학진。선택성년건강체검자40례위대조조；채용방면법측정혈청중백세포개소6、종류배사인자α적함량，응용목측류비평분법측정환자동통정도。결과시험조혈청백세포개소6、종류배사인자α、백세포개소1β함량현저고우대조조（P<0．05），차시험조중중도동통조상술혈청세포인자함량역현저고우경도동통조（P<0．05）。결론경추병중동통환자혈청백세포개소6、종류배사인자α、백세포개소1β명현승고시도치동통적인소。
Objective To analyze the relationship between the expression of serum cytokines and pain in patients with cervical spondylosis,so as to deepen the cognition of cervical spondylosis. Methods Forty-eight outpatients and inpatients with pain of cervical spondylosis in our hospital from January 2012 to December 2012 were selected as the experimental group. The cervical spondylosis was diagnosed according to the clinical symptoms combined with imaging examination. Meanwhile,40 healthy people were selected as the control group. The content of interleukin 6(lL6) and tumor necrosis factorα(TNF α) were determined with radioimmunology method.The serum lev-els of interleukin 6 (IL-6) and tumor necrosis factor(TNF-) were determined by radioimmuno-as-say. And the pain was measured by visual analogue scale. Results The serum levels of IL-6, TNF-α and IL-1β in the experimental group were significantly higher than those in the control group(P<0.05). And their serum levels in patients with severe pain were higher than those in pa-tients with light pain (P<0.05). Conclusion The serum levels of IL-6,TNF-α and IL-1β in pa-tients with pain of cervical spondylosis are very high,which maybe the factors lead the pain.