CAJ | 학술논문

目的：探讨nm23在乳腺癌在乳腺癌中的表达及其与预后的关系。方法收集2007年～2010年乳腺癌根治术标本105例，采用免疫组化法检测乳腺癌中nm23，雌激素受体（ER），孕激素受体（PR）和C-erbB-2的表达，并分析nm23与预后因子ER，PR和C-erbB-2及淋巴结转移的关系。结果 nm23阳性率为45．7％，其表达与预后正性因子ER，PR呈正相关，而与预后负性因子C-erbB-2、腋窝淋巴结转移呈负相关，其差异有显著性（ P＜0．05）。结论 nm23高表达是乳腺癌预后的正性相关因子之一。
목적：탐토nm23재유선암재유선암중적표체급기여예후적관계。방법수집2007년～2010년유선암근치술표본105례，채용면역조화법검측유선암중nm23，자격소수체（ER），잉격소수체（PR）화C-erbB-2적표체，병분석nm23여예후인자ER，PR화C-erbB-2급림파결전이적관계。결과 nm23양성솔위45．7％，기표체여예후정성인자ER，PR정정상관，이여예후부성인자C-erbB-2、액와림파결전이정부상관，기차이유현저성（ P＜0．05）。결론 nm23고표체시유선암예후적정성상관인자지일。
Objective To explore the expression and prognosis predicting value of nm 23 in breast cancer . Methods The expression of nm23,ER,PR and C-erbB-2 were detected by IHC method in 105 cases of breast cancer since 2007 to 2010.The correlation between nm23 and ER,PR,C-erbB-2 and lymphnode metastasis were analyzed .Re-sults The over expression of nm23 exists in 48 cases of 105 breast cancer(45.7%).It was positively related with prog-nosis-positive predicting factors such as ER ,PR,while negatively related with prognosis-negative predicting factors such as C-erbB-2 and lymphnode metastasis .Conclusion In breast cancer ,the over expression of nm23 was one of the posi-tive prognosis predicting factors .