CAJ | 학술논문

目的：探讨乳腺癌组织中TopoⅡα的表达及其与一线应用蒽环类药物化疗疗效的关系。方法应用免疫组化法检测TopoⅡα在63例乳腺癌组织中的表达并分析其意义。结果 TopoⅡα在乳腺癌组织中的阳性表达率为73．0％．TopoⅡα的阳性表达与年龄、肿瘤大小、位置、有无腋窝淋巴结转移及ER，PR的表达无明显相关性（P＞0．05），而与Her-2的表达有关（P＝0．026），且呈正相关性。应用蒽环类药物化疗的患者中，TopoⅡα阳性表达者有效率是TopoⅡα阴性表达者的3．077倍（P＝0．032）。TopoⅡα阳性表达组的无病进展期较TopoⅡα阴性表达组明显延长。结论 TopoⅡα的表达对乳腺癌患者化疗药物的选择及预后的判断具有重要的指导价值。
목적：탐토유선암조직중TopoⅡα적표체급기여일선응용은배류약물화료료효적관계。방법응용면역조화법검측TopoⅡα재63례유선암조직중적표체병분석기의의。결과 TopoⅡα재유선암조직중적양성표체솔위73．0％．TopoⅡα적양성표체여년령、종류대소、위치、유무액와림파결전이급ER，PR적표체무명현상관성（P＞0．05），이여Her-2적표체유관（P＝0．026），차정정상관성。응용은배류약물화료적환자중，TopoⅡα양성표체자유효솔시TopoⅡα음성표체자적3．077배（P＝0．032）。TopoⅡα양성표체조적무병진전기교TopoⅡα음성표체조명현연장。결론 TopoⅡα적표체대유선암환자화료약물적선택급예후적판단구유중요적지도개치。
Objective To explore whether the expression of TopoⅡαinfluences the response to anthracycline-containing first-line regimens in breast cancer .Methods The expression of TopoⅡαwere detected by immunohistochemistry in breast cancer from 63 cases, and its clinical significance was analysed .Results The expression rate of TopoⅡαin breast cancer were 73.0%.The expressions of TopoⅡαwere associated with Her-2(P=0.026),but not with age,tumor size,site,lymph node metastasis,ER and PR(P>0.05).The effective rate of TopoⅡαpositive expression applying anthracene ring chemotherapy drugs was 3.077 times than Topo Ⅱαnegative expression ( P=0.032).The time to progression of the group of TopoⅡαpositive expression was significantly longer than the group of Topo Ⅱαnegative ex-pression.Conclusion The expression of topoisomerase Ⅱin breast cancer contributes to the selection of drug in chemotherapy and prognosis evalation of breast caner .