中国临床保健杂志
中國臨床保健雜誌
중국림상보건잡지
CHINESE JOURNAL OF CLINICAL HEALTHCARE
2013年
5期
498-500
,共3页
付玉静%谢玉翠%翟建军
付玉靜%謝玉翠%翟建軍
부옥정%사옥취%적건군
外阴疾病%血管内皮生长因子类%血管内皮生长因子受体1%血管内皮生长因子受体2
外陰疾病%血管內皮生長因子類%血管內皮生長因子受體1%血管內皮生長因子受體2
외음질병%혈관내피생장인자류%혈관내피생장인자수체1%혈관내피생장인자수체2
Vulvar diseases%Vascular endothelial growth factors%Vascular endothelial growth factor receptor-1%Vascular endothelial growth factor receptor-2
目的：检测血管内皮生长因子受体1和2（ VEGF受体Flt-1与KDR/Flk-1）在外阴白色病变组织中的表达水平，探讨其在外阴白色病变发病的意义。方法应用免疫组织化学方法对39例外阴白色病变组织中Flt-1和KDR/Flk-1的表达情况进行检测，并以11例正常外阴皮肤组织作为对照，了解其相关性。结果应用直线相关软件对Flt-1与KDR/Flk-1阳性表达情况进行统计分析发现，两者之间存在一定正相关（r＝0．488，P＝0．002）。结论外阴白色病变皮损中VEGF受体Flt-1与KDR/Flk-1的表达异常，可能是导致病变的原因之一。
目的：檢測血管內皮生長因子受體1和2（ VEGF受體Flt-1與KDR/Flk-1）在外陰白色病變組織中的錶達水平，探討其在外陰白色病變髮病的意義。方法應用免疫組織化學方法對39例外陰白色病變組織中Flt-1和KDR/Flk-1的錶達情況進行檢測，併以11例正常外陰皮膚組織作為對照，瞭解其相關性。結果應用直線相關軟件對Flt-1與KDR/Flk-1暘性錶達情況進行統計分析髮現，兩者之間存在一定正相關（r＝0．488，P＝0．002）。結論外陰白色病變皮損中VEGF受體Flt-1與KDR/Flk-1的錶達異常，可能是導緻病變的原因之一。
목적：검측혈관내피생장인자수체1화2（ VEGF수체Flt-1여KDR/Flk-1）재외음백색병변조직중적표체수평，탐토기재외음백색병변발병적의의。방법응용면역조직화학방법대39예외음백색병변조직중Flt-1화KDR/Flk-1적표체정황진행검측，병이11례정상외음피부조직작위대조，료해기상관성。결과응용직선상관연건대Flt-1여KDR/Flk-1양성표체정황진행통계분석발현，량자지간존재일정정상관（r＝0．488，P＝0．002）。결론외음백색병변피손중VEGF수체Flt-1여KDR/Flk-1적표체이상，가능시도치병변적원인지일。
Objective To investigate the levels of vascular endothelial growth factor receptors ( Flt-1 and KDR/Flk-1) in the tissue of white lesion of vulva ,and to explore its significance in the pathogenesis of white lesions of vulva.Methods Biopsies from 39 patients with white lesions of vulvar (11 cases with LS,19 cases with SH,9 ca-ses with SH and LS ) were collected and the level of Flt-1 and KDR/Flk-1 were detected by immunohistochemistry . And normal vulgar tissues from 11 healthy patients were recruited as control .Results The immno-positive of Flt-1 and KDR/Flk-1 were positive correlative relationship .Conclusion The abnormal of VEGF receptors ( Flt-1 and KDR/Flk-1) in the tissue of white lesions of the vulva maybe play an important role in the etiology of this disease .
