CAJ | 학술논문

目的建立大鼠腹主动脉瘤血管移植动物模型。方法用SD大鼠，经麻醉后取胸腹联合切口切开暴露胸主动脉。取2cm长度胸主动脉，将其一端结扎，另一端端侧缝合于另外一只同系基因型大鼠的肾下腹主动脉形成动脉瘤。结果成功移植的SD大鼠术后均可长期生存。结论该模型方法虽然需要一定的显微外科手术技巧，但可作为动脉瘤，尤其为颅外动脉瘤研究的理想模型。
목적건립대서복주동맥류혈관이식동물모형。방법용SD대서，경마취후취흉복연합절구절개폭로흉주동맥。취2cm장도흉주동맥，장기일단결찰，령일단단측봉합우령외일지동계기인형대서적신하복주동맥형성동맥류。결과성공이식적SD대서술후균가장기생존。결론해모형방법수연수요일정적현미외과수술기교，단가작위동맥류，우기위로외동맥류연구적이상모형。
Objective To establish a rat model of abdominal aortic aneurysm via vascular transplantation. Methods The male SD rats served as donors and recipients ,and a bilateral thoracoabdominal incision was made to the donor animal after anesthesia .A segment of donor descending thoracic aorta was sutured end-to-side with continuous 9-0 nylon to the infrarenal abdominal aorta (approximate diameter, 1.5-2.0 mm in rats) of a syngenic recipient . The distal end of the graft was ligated, creating a pulsating saccular pouch (experimental aneurysm, 2.0-3.0 *4.0-5.0 mm). Results SD rats can receive long-term survival after a successful transplant . Conclusion Although it requires a certain microsurgery techniques,this ainimal model was a feasible model for study of aneurysm,particularly for extracranial aneurysm.