CAJ | 학술논문

目的：研究儿童狼疮性肾炎（LN）患者的肾活检（肾穿）病理参数对患者生存率（SR）和肾脏存活率（RSR）的影响。方法对67例做肾活检的儿童LN患者进行随访，按WHO关于LN的病理分型进行分类。用Kaplan-Maier曲线计算SR和RSR。用Cox比例风险模型分析肾穿病理参数对SR和RSR的独立预测价值。结果Log-rank检验结果显示儿童LN患者不同病理组间患者SR和RSR的有显著性差异。多变量Cox逐步回归分析，CI指数＞3对RSR的影响有显著的统计学差异。结论随着透析和肾移植的发展，直接死于肾衰竭的患者比例越来越少，儿童LN慢性肾衰竭后依靠透析生存良好。肾脏的慢性指数是RSR的独立危险因素。
목적：연구인동랑창성신염（LN）환자적신활검（신천）병리삼수대환자생존솔（SR）화신장존활솔（RSR）적영향。방법대67례주신활검적인동LN환자진행수방，안WHO관우LN적병리분형진행분류。용Kaplan-Maier곡선계산SR화RSR。용Cox비례풍험모형분석신천병리삼수대SR화RSR적독립예측개치。결과Log-rank검험결과현시인동LN환자불동병리조간환자SR화RSR적유현저성차이。다변량Cox축보회귀분석，CI지수＞3대RSR적영향유현저적통계학차이。결론수착투석화신이식적발전，직접사우신쇠갈적환자비례월래월소，인동LN만성신쇠갈후의고투석생존량호。신장적만성지수시RSR적독립위험인소。
Objective To assess the contribution of renal biopsy parameters to predicting the disease outcomes in children patients with lupus nephritis (LN). Methods Sixty-seven cases of LN in children who had received biopsy were studied for the survival rate (SR) and renal survival rate (RSR). Renal biopsy variables were assessed to determine whether they contributed additional predictive value for SR and RSR. Results The SR or RSR differences among the six WHO classes had statistical significance. Multivariate analysis showed that CI>3 had influence on the renal survival rate (RSR). Conclusion With the development of dialysis and renal transplantation,the numbers of patient who direatly die of renal failure are becoming less and less,and chidren with lupus nephritis (LN) who developed chronic renal failure can have high survival rate by dialysis. The prognositic factors associated with the renal survival rate in chidren with lupus nephritis(LN) is CI.