CAJ | 학술논문

目的：通过喘息性支气管炎患儿血清25-羟基维生素D水平的测定，探讨血清维生素D水平与喘息性支气管炎发病的关系，为小儿喘息性疾病的治疗提供新的理论和临床依据。方法：选择儿科门诊喘息性支气管炎患儿80例，随机分为VitD治疗组和非VitD治疗组，以同期健康体检儿30例作为对照组。采用液相色谱串联质谱技术检测血清25-羟基维生素D水平；同时记录喘息性支气管炎患儿临床症状的缓解时间以及半年喘息再发次数。结果：（1）治疗前VitD治疗组较对照组血清25-羟基维生素D水平低，2组比较差异均有统计学意义（P＜0．01）。（2）VitD治疗组较非VitD治疗组临床症状的缓解较快，半年喘息再发次数较少，2组比较差异均有统计学意义（P＜0．05）。结论：VitD缺乏与喘息性支气管炎发病密切相关，可能是喘息性支气管炎的潜在病因。在喘息性支气管炎的治疗过程中，补充VitD可及时缓解临床症状，降低喘息再发率。
목적：통과천식성지기관염환인혈청25-간기유생소D수평적측정，탐토혈청유생소D수평여천식성지기관염발병적관계，위소인천식성질병적치료제공신적이론화림상의거。방법：선택인과문진천식성지기관염환인80례，수궤분위VitD치료조화비VitD치료조，이동기건강체검인30례작위대조조。채용액상색보천련질보기술검측혈청25-간기유생소D수평；동시기록천식성지기관염환인림상증상적완해시간이급반년천식재발차수。결과：（1）치료전VitD치료조교대조조혈청25-간기유생소D수평저，2조비교차이균유통계학의의（P＜0．01）。（2）VitD치료조교비VitD치료조림상증상적완해교쾌，반년천식재발차수교소，2조비교차이균유통계학의의（P＜0．05）。결론：VitD결핍여천식성지기관염발병밀절상관，가능시천식성지기관염적잠재병인。재천식성지기관염적치료과정중，보충VitD가급시완해림상증상，강저천식재발솔。
Objective :By measuring children with asthmatic bronchitis serum 25-hydroxy vitamin D levels ,and to ex-plore the relationship between serum vitamin D levels and incidence of asthmatic bronchitis ,and provide a new theoreti-cal and clinical basis for the treatment of asthmatic disease .Methods :80 cases of pediatric outpatient children with asth-matic bronchitis ,were randomly divided into the VitD treatment group and the non-VitD treatment group .Healthy chil-dren during the same period 30 cases (control group) as a control .By liquid chromatography-tandem mass spectrome-try to detect serum 25-hydroxyvitamin D levels ;simultaneously record the duration of remission of clinical symptoms ,as well as six months ,the number of respite recurrence .Results:VitD tveatmert group compared with the control group serum 25-hydroxy D levels were statistically significant difference (P< 0 .01) .VitD treatment group compared with non-rapid remission of clinical symptoms of VitD treatment group ,six months respite recurrence less frequently ,two group differences were statistically significant (P<0 .05) .Conclusion:The VitD lack is closely related to the pathogen-esis of asthmatic bronchitis , may be the underlying cause of asthmatic bronchitis .Asthmatic bronchitis treatment process ,the supplement VitD alleviate clinical symptoms ,reduce respite recurrence rate .