CAJ | 학술논문

目的：观察替吉奥胶囊治疗老年晚期胃癌的疗效和不良反应。方法：选择39例老年进展期胃癌患者为研究对象，根据患者的体表面积分3个剂量等级给予替吉奥胶囊口服，给药4周后停药2周，6周为一个治疗周期，完成2个周期后评价疗效和不良反应。结果：全组39例患者1例完全缓解，12例部分缓解，11例病情稳定，15例病情进展，治疗完全缓解率为2.6%，治疗有效率为33.33%，肿瘤控制率为61.53%。随访至2013年11月，患者中位疾病进展时间为5.2个月，中位生存期为9.5个月。主要不良反应为骨髓抑制、胃肠道反应、色素沉着等，全组未出现因不能耐受不良反应而终止治疗的患者，且无治疗相关性死亡者。结论：替吉奥是治疗老年进展期胃癌安全、有效的药物，值得临床进一步研究和应用。
목적：관찰체길오효낭치료노년만기위암적료효화불량반응。방법：선택39례노년진전기위암환자위연구대상，근거환자적체표면적분3개제량등급급여체길오효낭구복，급약4주후정약2주，6주위일개치료주기，완성2개주기후평개료효화불량반응。결과：전조39례환자1례완전완해，12례부분완해，11례병정은정，15례병정진전，치료완전완해솔위2.6%，치료유효솔위33.33%，종류공제솔위61.53%。수방지2013년11월，환자중위질병진전시간위5.2개월，중위생존기위9.5개월。주요불량반응위골수억제、위장도반응、색소침착등，전조미출현인불능내수불량반응이종지치료적환자，차무치료상관성사망자。결론：체길오시치료노년진전기위암안전、유효적약물，치득림상진일보연구화응용。
Objective:To evaluate the therapeutic effects and adverse reactions of S-1 on elderly advanced gastric cancer. Method:Thirty-nine elderly patients with advanced gastric cancer were selected and treated with different doses of S-1 capsule according to the body surface areas for 4 weeks,then entered a 2-week treatment-free withdrawal period,a treatment cycle equal to 6 weeks. The therapeutic effects and adverse effects were evaluated after 2 cycles. Result:The complete response rate was 2.6%(1 of 39 patients),partial response rate and tumor control rate were respectively 33.3%(13 of 39 patients)and 61.5%(24 of 39 patients). Follow-up visits were made until November 2013,the time to progression(TTP) was 5.2 months,while the median survival time(MST)was 9.5 months. The major adverse effects such as myelosuppression, gastrointestinal reaction and cutaneous pigmentation were all observed,but there was no patient that discontinued treatment due to adverse events and no treatment-related deaths. Conclusion:S-1 is safe and effective in the treatment of advanced gastric cancer,especially for patients old and frail. It is worth further research and application in clinic.