CAJ | 학술논문

目的：分析小剂量肝素治疗急性白血病前弥漫性血管内凝血（pre-DIC）的效果及安全性。方法48例患者随机分为2组，对照组（n=24）采用常规治疗，观察组（n=24）常规治疗加小剂量肝素皮下注射，对比两组临床指标及不良反应。结果观察组治疗后血小板计数、凝血酶原时间（PT）、D-二聚体含量均与对照组有显著性差异（P＜0.05）；观察组转化为DIC比例显著低于对照组（P＜0.05）；两组均未出现严重的出血症状。结论小剂量肝素治疗能够有效阻止急性白血病前弥漫性血管内凝血向DIC发展。
목적：분석소제량간소치료급성백혈병전미만성혈관내응혈（pre-DIC）적효과급안전성。방법48례환자수궤분위2조，대조조（n=24）채용상규치료，관찰조（n=24）상규치료가소제량간소피하주사，대비량조림상지표급불량반응。결과관찰조치료후혈소판계수、응혈매원시간（PT）、D-이취체함량균여대조조유현저성차이（P＜0.05）；관찰조전화위DIC비례현저저우대조조（P＜0.05）；량조균미출현엄중적출혈증상。결론소제량간소치료능구유효조지급성백혈병전미만성혈관내응혈향DIC발전。
Objective To analysis the therapeutic effect and safety of Low-Dose heparin therapy for acute leukemia with pre-diffuse intravascular coagulation. Method 48 cases randomly divided into 2 groups. The control group(n=24) took conventional treatment. The observation group (n=24)took conventional treatment accompany with low-dose heparin subcutaneous. Clinical indicators and adverse reaction were contrasted between the two groups. Result After treatment, there has significant different in platelet count, fibrinogen level and D-dimer level between the two groups (P<0.05). Rate of developing into DIC were lower in the observation group than that in the control group (P<0.05). None severe bleeding tendency exist. Conclusion Low-dose heparin therapy can effectively interrupt pre-DIC development to DIC.