CAJ | 학술논문

目的探讨中医药对高效抗逆转录病毒治疗（HAART）疗法不良反应的临床疗效。方法采用随机对照法将60例采用 HAART常规治疗的 HIV/AIDS患者分为 HAART联合中药组和 HAART组，分别采用中西医结合治疗和西药治疗，观察患者治疗前、后3个月的临床症状与体征，计算卡洛夫斯基积分，检测血白细胞、红细胞、血色素、血小板、肝功能、肾功能、CD4细胞等。结果 HAART联合中药组和 HAART组治疗后症状均改善明显，积分均明显下降（P＜0．05），HAART联合中药组显效率、有效率高于 HAART组；两组治疗后体质量均有增加，但增加幅度均不明显；两组治疗后 CD4计数均增高（P＜0．05），中西医结合治疗后波动范围不大，基本处于稳定状态；两组卡洛夫斯基积分显著上升，HAART联合中药组与治疗前比较差异有统计学意义（P＜0．05）。HAART组卡洛夫斯基积分有所上升但差异无统计学意义（P≥0．05）；HAART联合中药组实验室指标 ALT、AST无效率低于 HAART组，有效率及稳定率无明显升高；HAART联合中药组指标BUN、CR、无效率与 HAART组一致，但无明显升高；HAART联合中药组实验室指标 WBC、RBC、PLT和 MCHC无效率明显低于 HAART组。结论中药与 HAART联用，可以有效缓解由 HAART导致的不良反应，在保证用药安全性的同时对患者血常规异常有一定的改善作用，能纠正部分患者的贫血，从而有效提高患者生存质量，改善患者依从性。
목적탐토중의약대고효항역전록병독치료（HAART）요법불량반응적림상료효。방법채용수궤대조법장60례채용 HAART상규치료적 HIV/AIDS환자분위 HAART연합중약조화 HAART조，분별채용중서의결합치료화서약치료，관찰환자치료전、후3개월적림상증상여체정，계산잡락부사기적분，검측혈백세포、홍세포、혈색소、혈소판、간공능、신공능、CD4세포등。결과 HAART연합중약조화 HAART조치료후증상균개선명현，적분균명현하강（P＜0．05），HAART연합중약조현효솔、유효솔고우 HAART조；량조치료후체질량균유증가，단증가폭도균불명현；량조치료후 CD4계수균증고（P＜0．05），중서의결합치료후파동범위불대，기본처우은정상태；량조잡락부사기적분현저상승，HAART연합중약조여치료전비교차이유통계학의의（P＜0．05）。HAART조잡락부사기적분유소상승단차이무통계학의의（P≥0．05）；HAART연합중약조실험실지표 ALT、AST무효솔저우 HAART조，유효솔급은정솔무명현승고；HAART연합중약조지표BUN、CR、무효솔여 HAART조일치，단무명현승고；HAART연합중약조실험실지표 WBC、RBC、PLT화 MCHC무효솔명현저우 HAART조。결론중약여 HAART련용，가이유효완해유 HAART도치적불량반응，재보증용약안전성적동시대환자혈상규이상유일정적개선작용，능규정부분환자적빈혈，종이유효제고환자생존질량，개선환자의종성。
Objective To analyze the clinical efficacy of traditional medicine for adverse drug reaction of highly active antiretro-viral therapy(HAART)medication.Methods 60 patients with AIDS received conventional treatment with HAART were randomly divided into the treatment group and control group.Traditional medicine was observed in patients of treatment group for more than 3 months,and several necessary test items were recorded before and after research.Results After therapy,the clinical symptoms weight,Karnofsky performance scale(KPS)and CD4 cells of the patients in two groups was obviously improved.Comparing with the control group,treatment group had better significant efficiency in the symptom,increased CD4 cell(P<0.05)and KPS(P<0.05).Inefficiency of ALT and AST in treatment group was lower than control group,while efficiency and stability had no signifi-cant increase.Inefficiency of WBC,RBC,PLT and MCHC in treatment group was significant higher than control group.Conclusion Traditional medicine combine with HAART for HIV/AIDS can decrease the incidence of adverse drug reaction of HAART medi-cation.For patients,the combination have the efficiency on protecting the safety of prescription and improving the routine blood test.The Traditional medicine may play a role in attenuation and synergy and improve the condition and prognosis of patients.