CAJ | 학술논문

目的：测定先天性白内障大鼠血液常规、生化正常值及血液流变学变化。方法采用XS-800i血常规分析仪和OLYMPUS AV2700生化自动分析仪对185～211 g大鼠共计90只进行血液常规和生化检测及用SA-6600自动血流变测试仪对血液进行流变学的测定。结果血像检测结果是白内障与正常对照同性比较无差异显著性（P ＞0.05）；小眼白内障与正常对照同性比较红细胞宽度（RDW）间差异显著（P ＜0.01或 P ＜0.05）。血生化检测结果是白内障大鼠与正常对照组同性间比较白蛋白（ALB）差异显著（P ＜0.01或P ＜0.05）雌性与对照组比较尿素（Ure）差异显著（P ＜0.01），小眼白内障雌性与正常对照比较肌酐（Cr）差异非常显著（P ＜0.01）。白内障、小眼白内障大鼠的红细胞是雄性的低于雌性（P ＜0.05，P ＜0.01）而血小板是雄性的高于雌性（P ＜0.01），肌酐是雄性低于雌性P ＜0.01），正常组雄雌间无差异；血液流变学各组间无差异显著性。结论白内障大鼠与正常组大鼠间某些血常规及生化指标有一定的差异，该数据为该鼠在这领域的使用提供参考。
목적：측정선천성백내장대서혈액상규、생화정상치급혈액류변학변화。방법채용XS-800i혈상규분석의화OLYMPUS AV2700생화자동분석의대185～211 g대서공계90지진행혈액상규화생화검측급용SA-6600자동혈류변측시의대혈액진행류변학적측정。결과혈상검측결과시백내장여정상대조동성비교무차이현저성（P ＞0.05）；소안백내장여정상대조동성비교홍세포관도（RDW）간차이현저（P ＜0.01혹 P ＜0.05）。혈생화검측결과시백내장대서여정상대조조동성간비교백단백（ALB）차이현저（P ＜0.01혹P ＜0.05）자성여대조조비교뇨소（Ure）차이현저（P ＜0.01），소안백내장자성여정상대조비교기항（Cr）차이비상현저（P ＜0.01）。백내장、소안백내장대서적홍세포시웅성적저우자성（P ＜0.05，P ＜0.01）이혈소판시웅성적고우자성（P ＜0.01），기항시웅성저우자성P ＜0.01），정상조웅자간무차이；혈액류변학각조간무차이현저성。결론백내장대서여정상조대서간모사혈상규급생화지표유일정적차이，해수거위해서재저영역적사용제공삼고。
Objective To measure the range of routine blood counts and blood biochemical parameters ,to analyze hemorheology of the rats with congenital cataract .Methods Blood samples were taken from 90 rats with congenital cataract weight about 185 ~211 g.Routine blood analysis was performed and blood biochemical and hemorheology paramenters were determind using an automatic blood biochemical and hemorheology analyzer .Results There were no significant difference ( P >0.05 ) between the cataract rats and the normal rats in Blood test results; but there were significant difference between the microphthalmos cataract rats and the normal same -sex rats ( P <0.01 or P <0.05 ) . The biochemical results is the cataract rats and the normal rats were different significantly in ALB group ( P <0.01 or P<0.05), and the female microphthalmos cataract rats compared with the control rats had significant difference in Ure (P<0.01) , the female cataract rats ompared with the normal rats were very significant difference in Cr group ( P <0.05 or P <0.01).The erythrocyte counts of the male cataract rats and male microphthalmos cataract rats were significantly lower than that in the female ones, respectively(P <0.05, P <0.01).The platelet counts of the male cataract rats and the male microphthalmos cataract rats were significantly higher than that in the female ones , respectively(P <0.01), and the creatinine of the male cataract rats and the male microphthalmos cataract rats were significantly lower then that in the female ones, respectively(P <0.01).There were no significant difference in every group on hemorheology .Conclusions There were significant differences in some blood indexes between the congenital cataract rats and the normal rats .These data may become useful reference for biomedical researcher in this field .