CAJ | 학술논문

目的：探讨高同型半胱氨酸（Homoeysteine，Hcy）与帕金森病（Parkinson's disease，PD）、帕金森临床分级及帕金森病认知功能的相关性。方法选择87例30~85岁的门诊健康体检者作为对照组，66例30~85岁帕金森病患者纳入研究，为PD组，登记病史及详细体检，行UPDRS评分及Hoehn-Yahr分级，通过MMSE及Moca量表筛查认知功能障碍患者，把PD组分为认知功能障碍组和认知功能正常组两个亚组。测定空腹Hcy，对比分析PD患者患病率及其病情分级与Hcy水平是否存在相关性，对比PD患者认知功能障碍与Hcy水平是否也存在关联性。结果 PD组同型半胱氨酸水平明显较对照组高。 PD认知功能障碍组同型半胱氨酸水平高于PD认知功能正常组。同型半胱氨酸水平与PD严重程度无相关性。结论高同型半胱氨酸很可能为帕金森病及帕金森病认知功能障碍的危险因素之一，但不可以用来评定疾病严重程度。
목적：탐토고동형반광안산（Homoeysteine，Hcy）여파금삼병（Parkinson's disease，PD）、파금삼림상분급급파금삼병인지공능적상관성。방법선택87례30~85세적문진건강체검자작위대조조，66례30~85세파금삼병환자납입연구，위PD조，등기병사급상세체검，행UPDRS평분급Hoehn-Yahr분급，통과MMSE급Moca량표사사인지공능장애환자，파PD조분위인지공능장애조화인지공능정상조량개아조。측정공복Hcy，대비분석PD환자환병솔급기병정분급여Hcy수평시부존재상관성，대비PD환자인지공능장애여Hcy수평시부야존재관련성。결과 PD조동형반광안산수평명현교대조조고。 PD인지공능장애조동형반광안산수평고우PD인지공능정상조。동형반광안산수평여PD엄중정도무상관성。결론고동형반광안산흔가능위파금삼병급파금삼병인지공능장애적위험인소지일，단불가이용래평정질병엄중정도。
Objective To discuss the relationships between homoeysteine levels and clinical stages,cognitive dysfunc-tion in Parkinson's disease (PD). Methods Eighty-seven cases of healthy person were collected from the health examination centers as control group. Sixty-six patients of PD were enrolled. And recorded their history,detailed physical examination UPDRS and Hoehn-Yahr scal. The patients of PD were randomized into two groups with reference to the score of MMSE and Moca, in-cluding the cognition impairment group and the normal cognition group. The levels of homoeysteine in the two groups were ex-amined and compared. Results The homoeysteine levels in PD group were significantly higher than those in normal control group. The homoeysteine levels in the cognition impairment group were higher than those in normal cognition group. There was no correlation between homoeysteine levels and severity of PD. Conclusion High level of the homoeysteine may be one of the risk factors for PD and its cognitive impairment,but cannot be used to assess the severity of the disease.