CAJ | 학술논문

目的：探讨血清胱抑素C（Cys C）水平与不同糖耐量患者颈动脉粥样硬化的相关性。方法选取糖耐量正常者（NGT组）30例、糖耐量异常患者（IGT组）60例、新诊断2型糖尿病患者（T2DM组）60例，检测3组受试者血生化指标及血清Cys C水平，用超声检测颈动脉内膜中层厚度（IMT）。结果3组受试者血清Cys C水平及颈动脉IMT逐渐增高，组间两两比较差异有统计学意义（P<0.05）。多元Logistic回归分析显示，血清Cys C、高敏C反应蛋白（hs-CRP）、胰岛素抵抗指数（HOMA-IR）和低密度脂蛋白（LDL-C）是颈动脉粥样硬化的独立危险因素。结论糖代谢异常早期即存在高血清Cys C水平，并参与了糖尿病动脉硬化的进程。
목적：탐토혈청광억소C（Cys C）수평여불동당내량환자경동맥죽양경화적상관성。방법선취당내량정상자（NGT조）30례、당내량이상환자（IGT조）60례、신진단2형당뇨병환자（T2DM조）60례，검측3조수시자혈생화지표급혈청Cys C수평，용초성검측경동맥내막중층후도（IMT）。결과3조수시자혈청Cys C수평급경동맥IMT축점증고，조간량량비교차이유통계학의의（P<0.05）。다원Logistic회귀분석현시，혈청Cys C、고민C반응단백（hs-CRP）、이도소저항지수（HOMA-IR）화저밀도지단백（LDL-C）시경동맥죽양경화적독립위험인소。결론당대사이상조기즉존재고혈청Cys C수평，병삼여료당뇨병동맥경화적진정。
Objective To investigate the changes of serum cystatin C levels in different glucose tolerance patients,as well as the correlation of these changes with carotid atherosclerosis. Methods 150 people were divided into 3 groups includ-ing normal glucose tolerance group (NGT group,n=30),impaired glucose tolerance group (IGT group,n=60) and newly diag-nosed type 2 diabetes mellitus group (T2DM group,n=60). Serum cystatin C,carotid intima-media thickness and other indicators were tested and analyzed. Results Serum cystatin C levels and carotid intima-media thickness were gradually increased in 3 groups,with significant differences between any two groups (P<0.05). Multiple Logistic regression analysis showed that serum cystatin C,high sensitive C-reactive protein (hs-CRP),HOMA-IR and LDL-C were independently associated with carotid atherosclerosis. Conclusion Cystatin C plays an important role in diabetic arteriosclerosis during its progression.