国际脑血管病杂志
國際腦血管病雜誌
국제뇌혈관병잡지
INTERNATIONAL JOURNAL OF CEREBROVASCULAR DISEASES
2013年
2期
138-142
,共5页
脑缺血%缺血预处理%神经保护药%受体,N-甲基-D-天冬氨酸%受体,腺苷A1%KATP通道%类Toll受体%缺氧诱导因子1
腦缺血%缺血預處理%神經保護藥%受體,N-甲基-D-天鼕氨痠%受體,腺苷A1%KATP通道%類Toll受體%缺氧誘導因子1
뇌결혈%결혈예처리%신경보호약%수체,N-갑기-D-천동안산%수체,선감A1%KATP통도%류Toll수체%결양유도인자1
Brain Ischemia%Ischemic Preconditioning%Neuroprotective Agents%Receptors,N-Methyl-D-Aspartate%Receptor,Adenosine A1%KATP Channels%Toll-Like Receptors%Hypoxia-Inducible Factor 1
大量动物实验证实,缺血预处理可产生强大的器官保护作用,但动物实验向临床试验转化的进展和结果不尽如人意.对缺血预处理介导的神经保护的分子机制进行研究,寻找可转化到临床的安全且有效的预处理诱导方式,对于提高卒中和手术患者神经组织对缺血缺氧的耐受力,实现安全和有效的神经保护具有重要意义.文章从预处理活化受体、线粒体、转录因子和蛋白激酶等方面对缺血预处理介导神经保护的分子机制进行了综述.
大量動物實驗證實,缺血預處理可產生彊大的器官保護作用,但動物實驗嚮臨床試驗轉化的進展和結果不儘如人意.對缺血預處理介導的神經保護的分子機製進行研究,尋找可轉化到臨床的安全且有效的預處理誘導方式,對于提高卒中和手術患者神經組織對缺血缺氧的耐受力,實現安全和有效的神經保護具有重要意義.文章從預處理活化受體、線粒體、轉錄因子和蛋白激酶等方麵對缺血預處理介導神經保護的分子機製進行瞭綜述.
대량동물실험증실,결혈예처리가산생강대적기관보호작용,단동물실험향림상시험전화적진전화결과불진여인의.대결혈예처리개도적신경보호적분자궤제진행연구,심조가전화도림상적안전차유효적예처리유도방식,대우제고졸중화수술환자신경조직대결혈결양적내수력,실현안전화유효적신경보호구유중요의의.문장종예처리활화수체、선립체、전록인자화단백격매등방면대결혈예처리개도신경보호적분자궤제진행료종술.
A large number of animal experiments have confirmed that ischemic preconditioning can produce a powerful organ protective effect,but the progress and results of the conversion of animal experiments to clinical trials are unsatisfactory.It has great significance for studying of molecular mechanisms of ischemic preconditioning mediated neuroprotection,searching for safe and effective preconditioning induced ways which can be converted to clinical practice,improving the tolerance of nerve tissue ischemia and hypoxia in stroke and surgical patients and achieving a safe and effective neuroprotection.This article reviews the molecular mechanisms of ischemic preconditioning mediated neuroprotection from the aspects of pretreatment of activated receptor,mitochondria,transcription factor,and protein kinase.
