CAJ | 학술논문

慢性粒细胞白血病是一种造血干细胞的恶性克隆增殖性疾病，以分子生物学、免疫学、细胞生物学为基础的治疗手段成为新的研究方向。 siRNA介导的基因沉默通过降解靶标mRNA，miRNA介导的基因沉默通过使靶mRNA失去稳定性以减少蛋白质的生成，从而提高靶向治疗药物的治疗效果。过继免疫治疗是通过将CIK、NK等免疫活性细胞注入肿瘤宿主体内，提高机体免疫力，与靶向治疗药物协同提升治疗效果。其理论基础、分子机制、临床疗效等还需进一步深入研究。
만성립세포백혈병시일충조혈간세포적악성극륭증식성질병，이분자생물학、면역학、세포생물학위기출적치료수단성위신적연구방향。 siRNA개도적기인침묵통과강해파표mRNA，miRNA개도적기인침묵통과사파mRNA실거은정성이감소단백질적생성，종이제고파향치료약물적치료효과。과계면역치료시통과장CIK、NK등면역활성세포주입종류숙주체내，제고궤체면역력，여파향치료약물협동제승치료효과。기이론기출、분자궤제、림상료효등환수진일보심입연구。
Chronic myeloid leukemia is a kind of malignant cloning hyperplastic disease of hematopoietic stem cell .The treatments based on molecular biological and immunological techniques will become the new therapies .Gene silence can improve the effects of molecular targeted therapeutic drugs through two ways: one is the target mRNA can be digested by siRNA and the other is target gene lose the stability and reduce the generation of protein mediated by miRNA .Adoptive cel-lular immunotherapy is a treatment method through injecting immunocompetent cells such as CIK , NK, etc into the body of cancerous person .This can improve the immunity of body and the effects of molecular targeted therapeutic drugs .The fur-ther study about basic theory , molecular mechanism and clinical effects will be continued .