CAJ | 학술논문

以昆明种小鼠为研究对象，利用跳台实验、旷场实验和免疫印迹杂交等方法研究了肝源性磷脂对于增强小鼠学习记忆和空间探索能力的影响。结果表明：与对照组相比，预先给予高剂量肝磷脂补充可以显著提高小鼠的学习记忆以及空间探索能力；Western Blot结果显示，与正常组相比高剂量肝磷脂补充组小鼠脑内海马区Caveolin-1和PKC α蛋白的表达量明显升高。结果提示，肝源性磷脂可以通过激活Caveolin-1蛋白和PKC α蛋白的表达增强小鼠的学习和记忆能力。
이곤명충소서위연구대상，이용도태실험、광장실험화면역인적잡교등방법연구료간원성린지대우증강소서학습기억화공간탐색능력적영향。결과표명：여대조조상비，예선급여고제량간린지보충가이현저제고소서적학습기억이급공간탐색능력；Western Blot결과현시，여정상조상비고제량간린지보충조소서뇌내해마구Caveolin-1화PKC α단백적표체량명현승고。결과제시，간원성린지가이통과격활Caveolin-1단백화PKC α단백적표체증강소서적학습화기억능력。
To explore the impact of animal hepatic phospholipids on memory improving and space ex-ploring ,we took use of open-field and platform experiments and Western Blot analysis in this study . Results show that ,compared with the control groups ,high doses of hepatic phospholipids could sig-nificantly improve the ability of learning and memory ,as well as space exploring ;Western Blot re-sults show that the expressions of Caveolin-1 and PKC αin hippocampus area were obviously higher than those in control groups .Hepatic phospholipids improve the ability of learning and memory in mice after activating the Caveolin-1 and PKCαprotein expression and at the same time ,provide a sci-entific basis for the further development of phospholipids health care products .