CAJ | 학술논문

目的：为探讨绝经后骨质疏松症对颅骨造成的影响，建立去势大鼠模型，观察其颅骨骨密度、骨矿含量以及组织学改变。方法取2月龄未交配雌性SD大鼠40只，随机分为2组：A组为实验组20只，行双侧卵巢摘除术；B组为对照组20只，行假手术。模型建立完成后3个月处死大鼠，取颅骨，双能X线检测骨密度及骨矿含量，HE染色观察骨微观结构变化。结果双侧卵巢摘除术后3个月，大鼠颅骨骨密度：实验组为0．333±0．006g/cm2，对照组为0．402±0．035g/cm2；骨矿含量：实验组为：2．185±0．047g，对照组为：2．553±0．180g，两组骨密度（BMD）及骨矿含量具有明显差异（P＜0．05）。结论双侧卵巢摘除术所造成的绝经后骨质疏松症可引起大鼠颅骨骨密度、骨质量明显下降。
목적：위탐토절경후골질소송증대로골조성적영향，건립거세대서모형，관찰기로골골밀도、골광함량이급조직학개변。방법취2월령미교배자성SD대서40지，수궤분위2조：A조위실험조20지，행쌍측란소적제술；B조위대조조20지，행가수술。모형건립완성후3개월처사대서，취로골，쌍능X선검측골밀도급골광함량，HE염색관찰골미관결구변화。결과쌍측란소적제술후3개월，대서로골골밀도：실험조위0．333±0．006g/cm2，대조조위0．402±0．035g/cm2；골광함량：실험조위：2．185±0．047g，대조조위：2．553±0．180g，량조골밀도（BMD）급골광함량구유명현차이（P＜0．05）。결론쌍측란소적제술소조성적절경후골질소송증가인기대서로골골밀도、골질량명현하강。
Objective To explore the effects of osteoporosis on the skull,we established animal model of postmenopausal osteoporosis and observed the changes of skulls in bone mineral density,bone mineral content,and histology.Methods 2-month-old female SD rats (n=40)were randomly divided into 2 groups:the experimental group underwent bilateral ovariectomy;the control group underwent sham opera-tion.Three months after the operation,all rats were sacrificed and skulls were harvested.DEXA method was used to detect bone mineral densi-ty and bone mineral content,while HE staining was performed to access the trabeculae.Results Bone mineral density:the experimental group was (0.333 ±0.006)g/cm2,the control group was (0.402 ±0.035)g/cm2;bone mineral content:the experimental group was (2.185 ±0. 047)g,the control group was (2.553 ±0.180)g.The data were statistically significant (P<0.05).Conclusion Postmenopausal osteoporo-sis may result in obvious decrease in the bone mass and bone density of skulls.