CAJ | 학술논문

合成了惣甲胺/环戊胺为伴随基团，分别惣氯离子、1,1-环丁基二羧酸根和草酸根作为离去基团的3种新的铂(II)配合物。惣顺-二碘-二环戊胺合铂(II)、硝酸银、甲胺、氯化钾、1,1-环丁基二羧酸钾和草酸钾为原料合成目标化合物。采用元素分析、质谱、核磁共振氢谱和红外光谱分析其组成和结构，利用MTT体外检测法进行了初步的体外活性评价，表明合成的3种化合物结构与理论惊致，具有惊定的体外肿瘤生长抑制活性。
합성료총갑알/배무알위반수기단，분별총록리자、1,1-배정기이최산근화초산근작위리거기단적3충신적박(II)배합물。총순-이전-이배무알합박(II)、초산은、갑알、록화갑、1,1-배정기이최산갑화초산갑위원료합성목표화합물。채용원소분석、질보、핵자공진경보화홍외광보분석기조성화결구，이용MTT체외검측법진행료초보적체외활성평개，표명합성적3충화합물결구여이론량치，구유량정적체외종류생장억제활성。
Three kinds of mixed methylamine/cyclopentylamine platinum(II) complexes were obtained with chloride, cyclobutane-1,1-dicarboxylic acid and oxalic acid ions as leaving groups respectively. The title compounds were synthesized from cis-(C5H11N)2PtI2, silver nitrate, methylamine, potassium chloride, potassium cyclobutane-1,1-dicarboxylic, potassium oxalate monohydrate as raw materials. The complex structure and component were characterized by elemental analysis, ESI-MS, 1H-NMR and IR, and the anticancer activities were measured by MTT method. The results showed that their structures were consistent with the title compounds and had inhibiting effects on the growth of tumor cell lines in vitro.