福建医科大学学报
福建醫科大學學報
복건의과대학학보
JOURNAL OF FUJIAN MEDICAL UNIVERSITY
2013年
3期
141-145
,共5页
蔡江萍%洪诸权%洪全龙%魏晓兰%蔡俊颖
蔡江萍%洪諸權%洪全龍%魏曉蘭%蔡俊穎
채강평%홍제권%홍전룡%위효란%채준영
帕金森病%蛋白质丝氨酸苏氨酸激酶%LRRK2蛋白 ,人类%甘氨酸%精氨酸%疾病遗传易感性%多态现象 ,遗传%DNA突变分析%泉州%汉族
帕金森病%蛋白質絲氨痠囌氨痠激酶%LRRK2蛋白 ,人類%甘氨痠%精氨痠%疾病遺傳易感性%多態現象 ,遺傳%DNA突變分析%泉州%漢族
파금삼병%단백질사안산소안산격매%LRRK2단백 ,인류%감안산%정안산%질병유전역감성%다태현상 ,유전%DNA돌변분석%천주%한족
Parkinson disease%protein-serine-threonine kinases%LRRK2 protein,human%gly-cine%arginine%genetic predisposition to disease%polymorphism,genetic%DNA mutational analysis%Quanzhou%HAN nationality
目的探讨 LRRK2基因Gly2385Arg同泉州地区汉族人群散发性帕金森病(PD)的关系。方法收集268例泉州地区汉族散发性PD患者和277例健康者的外周血液标本并提取DNA ,利用聚合酶链反应(PCR)-限制性酶切方法(RFLP)进行 LRRK2基因Gly2385Arg多态位点的基因型检测,变异者进行直接测序验证。结果 Gly2385A rg检测中,PD组有26例是杂合型变异(9.7%),显著高于对照组(2.2%;P<0.01,OR:4.85,95%CI:1.96~11.99)。按性别分层显示:在男性亚组或女性亚组中,Gly2385Arg变异的频率在PD组均分别显著高于健康对照组(男性亚组:P<0.01,OR:4.07,95% C I:1.32~12.54;女性亚组:P<0.01,OR:6.44,95% C I:1.39~29.72)。按起病年龄分层显示,晚发型 PD (起病年龄>50岁)中,Gly2385Arg 变异的频率显著高于对照组(P<0.01,OR:4.44,95% CI:1.63~12.06);早发型PD(起病年龄≤50岁)中,Gly2385Arg变异的频率与对照组差别无意义。结论 LRRK2基因Gly2385Arg多态是泉州地区汉族人群晚发型PD的一个风险因子。
目的探討 LRRK2基因Gly2385Arg同泉州地區漢族人群散髮性帕金森病(PD)的關繫。方法收集268例泉州地區漢族散髮性PD患者和277例健康者的外週血液標本併提取DNA ,利用聚閤酶鏈反應(PCR)-限製性酶切方法(RFLP)進行 LRRK2基因Gly2385Arg多態位點的基因型檢測,變異者進行直接測序驗證。結果 Gly2385A rg檢測中,PD組有26例是雜閤型變異(9.7%),顯著高于對照組(2.2%;P<0.01,OR:4.85,95%CI:1.96~11.99)。按性彆分層顯示:在男性亞組或女性亞組中,Gly2385Arg變異的頻率在PD組均分彆顯著高于健康對照組(男性亞組:P<0.01,OR:4.07,95% C I:1.32~12.54;女性亞組:P<0.01,OR:6.44,95% C I:1.39~29.72)。按起病年齡分層顯示,晚髮型 PD (起病年齡>50歲)中,Gly2385Arg 變異的頻率顯著高于對照組(P<0.01,OR:4.44,95% CI:1.63~12.06);早髮型PD(起病年齡≤50歲)中,Gly2385Arg變異的頻率與對照組差彆無意義。結論 LRRK2基因Gly2385Arg多態是泉州地區漢族人群晚髮型PD的一箇風險因子。
목적탐토 LRRK2기인Gly2385Arg동천주지구한족인군산발성파금삼병(PD)적관계。방법수집268례천주지구한족산발성PD환자화277례건강자적외주혈액표본병제취DNA ,이용취합매련반응(PCR)-한제성매절방법(RFLP)진행 LRRK2기인Gly2385Arg다태위점적기인형검측,변이자진행직접측서험증。결과 Gly2385A rg검측중,PD조유26례시잡합형변이(9.7%),현저고우대조조(2.2%;P<0.01,OR:4.85,95%CI:1.96~11.99)。안성별분층현시:재남성아조혹녀성아조중,Gly2385Arg변이적빈솔재PD조균분별현저고우건강대조조(남성아조:P<0.01,OR:4.07,95% C I:1.32~12.54;녀성아조:P<0.01,OR:6.44,95% C I:1.39~29.72)。안기병년령분층현시,만발형 PD (기병년령>50세)중,Gly2385Arg 변이적빈솔현저고우대조조(P<0.01,OR:4.44,95% CI:1.63~12.06);조발형PD(기병년령≤50세)중,Gly2385Arg변이적빈솔여대조조차별무의의。결론 LRRK2기인Gly2385Arg다태시천주지구한족인군만발형PD적일개풍험인자。
Objective To investigate the relationship between the Gly 2385Arg polymorphism of leucine-rich repeat kinase 2 (LRRK2) gene and sporadic Parkinson’s disease(SPD) in the Han Chinese population in Quanzhou , China . Methods A total of 545 subjects from Han Chinese population in Quanzhou were enrolled ,including 277 control individuals and 268 patients with SPD . Genotyping of Gly2385Arg was performed by PCR-restriction fragment length polymorphism analysis ,and all variant samples were sequenced for further confirmation . Results The Gly2385Arg variant was significantly en-riched in the SPD patient group (9 .7% )compared with the control group(2 .2% ,P<0 .01 ,OR:4 .85 ,95%CI:1 .96~11 .99) . When the genders were analyzed separately ,the frequencies of this variant were sig-nificantly higher in both male and female patients than in the corresponding control group (males :P<0 .01 ,OR:4 .07 ,95% CI:1 .32~12 .54 ;females :P<0 .01 ,OR:6 .44 ,95% CI:1 .39~29 .72) . Stratifi-cation by age of onset showed this difference was only present in late-onset PD patients(P< 0 .01 ,OR:4 .44 ,95% CI:1 .63~12 .06) . Conclusion The Gly2385Arg polymorphism may be a risk factor for late-onset SPD in the Han Chinese population in Quanzhou .