CAJ | 학술논문

肝癌形成以及肿瘤侵袭和转移过程中癌细胞和癌旁基质之间的相互调节作为一个动态系统已被广泛研究。肝肿瘤微环境一般分为细胞成分和非细胞成分：细胞成分包括肝实质细胞、肝星状细胞、成纤维细胞、免疫细胞、内皮细胞、间充质干细胞；非细胞成分包括生长因子、细胞因子、细胞外基质、激素和病毒等。目前研究认为肝脏细胞成分在经历外界不同刺激后，通过促进细胞坏死、凋亡以及分泌多种蛋白形成炎症微环境，从而参与肝肿瘤的发生和发展。由于肝细胞癌引起死亡的主要原因是肿瘤的进展和转移，因此深入研究肿瘤转移过程中肝细胞与炎症微环境之间的相互作用将有助于系统性阐述肝癌转移的分子机理。
간암형성이급종류침습화전이과정중암세포화암방기질지간적상호조절작위일개동태계통이피엄범연구。간종류미배경일반분위세포성분화비세포성분：세포성분포괄간실질세포、간성상세포、성섬유세포、면역세포、내피세포、간충질간세포；비세포성분포괄생장인자、세포인자、세포외기질、격소화병독등。목전연구인위간장세포성분재경력외계불동자격후，통과촉진세포배사、조망이급분비다충단백형성염증미배경，종이삼여간종류적발생화발전。유우간세포암인기사망적주요원인시종류적진전화전이，인차심입연구종류전이과정중간세포여염증미배경지간적상호작용장유조우계통성천술간암전이적분자궤리。
The cross-talk between tumor cells and the surrounding peri-tumoral stroma has been extensively studied as a dynamic system involving the processes of hepatocarcinogenesis, tumor invasion and metastasis in recent few decades. Besides hepatocytes, liver tumor microenvironments are generally classified into cellular and non-cellular components, including hepatic stellate cells, fibroblasts, immune, endothelial, mesenchymal stem cells together with growth factors, cytokines, extracellular matrix (ECM), hormone as well as virus etc. The non-cellular components manipulate hepatocellular carcinoma (HCC) invasion and metastasis by facilitating epithelial-mesenchymal transition (EMT), increasing proteolytic activity of matrix metalloproteinases (MMPs), and regulating antitumor immunity, etc. Since the main cause of death in HCC patients is tumor progression with metastasis, a better understanding of the interplay between hepatocytes and their environment during tumor metastasis may be helpful for the discovery of novel molecular targets.