CAJ | 학술논문

目的探讨吉非替尼片辅助治疗非小细胞肺癌的临床疗效、安全性及其影响因素。方法选择我院46例既往接受化疗治疗效果不佳的非小细胞肺癌患者为研究对象，在对症支持治疗基础上加用吉非替尼片进行生物靶向治疗，治疗1个月后，观察治疗疗效及不良反应的发生情况，并分析影响疗效的因素。结果本组46例患者临床治疗显效30例（65.22％），有效16例（34.78％），未出现无效患者。共13例患者治疗过程中发生不良反应，总发生率为28.26％，其中严重不良反应4例，发生率为8.70％。因不良反应而被迫停止用药的患者仅有3例，其余患者采取相应措施后不良反应症状好转。性别、年龄、吸烟情况与 WHO 体力评分均与患者治疗后平均生存时间具有明显相关性，对吉非替尼治疗效果产生较大影响，吉非替尼治疗后患者临床症状得到明显改善。结论吉非替尼片辅助治疗非小细胞肺癌的临床疗效显著，但受患者年龄、性别、吸烟情况及 WHO 体力评分等多方面因素影响。
목적탐토길비체니편보조치료비소세포폐암적림상료효、안전성급기영향인소。방법선택아원46례기왕접수화료치료효과불가적비소세포폐암환자위연구대상，재대증지지치료기출상가용길비체니편진행생물파향치료，치료1개월후，관찰치료료효급불량반응적발생정황，병분석영향료효적인소。결과본조46례환자림상치료현효30례（65.22％），유효16례（34.78％），미출현무효환자。공13례환자치료과정중발생불량반응，총발생솔위28.26％，기중엄중불량반응4례，발생솔위8.70％。인불량반응이피박정지용약적환자부유3례，기여환자채취상응조시후불량반응증상호전。성별、년령、흡연정황여 WHO 체력평분균여환자치료후평균생존시간구유명현상관성，대길비체니치료효과산생교대영향，길비체니치료후환자림상증상득도명현개선。결론길비체니편보조치료비소세포폐암적림상료효현저，단수환자년령、성별、흡연정황급 WHO 체력평분등다방면인소영향。
Objective To explore the clinical efficacy, safety and influencing factors of auxiliary treatment of non-small cell lung cancer by Gefitinib tablets. Methods Forty-six patients with NSCLC whose previous chemotherapy treatment were not optimal were selected as the objects, and all patients received biological target therapy by Gefitinib Tablets, on the basis of sup-porting treatment with retention enema. The curative effects and adverse effects were observed and the influencing factors were analyzed after one month of treatment. Results Of 46 patients, 30 cases (65.22%) had marked improvement, and 16 cases (34.78%) had effective results, and no patient showed invalid results. A total of 13 patients had adverse reactions during the process of treat-ment, and the total incidence was 28.26%, including four cases with serious adverse events, with the incidence of 8.70%. Only three cases were forced to stop treatment due to adverse reactions, and the rest of the patients had symptoms of adverse reactions improved by taking corresponding measures. Gender, age, smoking status, and the WHO performance status score had obvious correlation with the patients average survival time after treatment, and had an impact on the therapeutic effects of Gefitinib Tab-lets. After treatment, patients’clinical symptoms significantly improved. Conclusion Gefitinib Tablets had obvious clinical curative effect in the auxiliary treatment of non-small cell lung cancer, however its curative results were affected by patients’age, gender, smoking status, and the WHO performance status score.