CAJ | 학술논문

目的探讨 MMP-13在甲状腺癌组织中的表达及其与疾病分期的关系。方法采用免疫组化法检测62例甲状腺癌患者的癌组织以及癌旁正常组织中 MMP-13蛋白的表达水平，分析 MMP-13表达与甲状腺癌临床分期的关系。结果甲状腺癌组织中 MMP-13蛋白表达的阳性率为77.4％（48/62），显著高于癌旁正常组织的8.1％（5/62）（P<0.05）；晚期（Ⅲ～Ⅳ期）甲状腺癌患者癌组织中 MMP-13蛋白表达的阳性率为94.7％（18/19），显著高于早期（Ⅰ～Ⅱ期）甲状腺癌患者的77.4％（48/62）（P<0.05）。结论甲状腺癌组织中 MMP-13蛋白的表达水平升高，MMP-13的高表达与甲状腺癌的疾病进展密切相关。
목적탐토 MMP-13재갑상선암조직중적표체급기여질병분기적관계。방법채용면역조화법검측62례갑상선암환자적암조직이급암방정상조직중 MMP-13단백적표체수평，분석 MMP-13표체여갑상선암림상분기적관계。결과갑상선암조직중 MMP-13단백표체적양성솔위77.4％（48/62），현저고우암방정상조직적8.1％（5/62）（P<0.05）；만기（Ⅲ～Ⅳ기）갑상선암환자암조직중 MMP-13단백표체적양성솔위94.7％（18/19），현저고우조기（Ⅰ～Ⅱ기）갑상선암환자적77.4％（48/62）（P<0.05）。결론갑상선암조직중 MMP-13단백적표체수평승고，MMP-13적고표체여갑상선암적질병진전밀절상관。
Objective To investigate the expression of MMP-13 in thyroid carcinoma tissues and the relationship between MMP-13 expression and the clinical stages. Methods The expressions of MMP-13 protein were detected by immunohisto-chemical staining in thyroid carcinoma tissues and para-carcinoma tissues of 62 cases. The relationship between MMP-13 ex-pression and thyroid carcinoma stage was analyzed. Results The positive expression rate of MMP-13 protein in thyroid cancer tissue was 77.4% (48/62), significantly higher than the rate of para-carcinoma tissues which was 8.1% (5/62) (P<0.05). The MMP-13 protein expression rate in late stages (Ⅲ~Ⅳ) of thyroid carcinoma was 94.7% (18/19), significantly higher than the rate of early stages (Ⅰ~Ⅱ) which was 77.4% (48/62) (P<0.05). Conclusions The expression of MMP-13 protein significantly increased in thyroid carcinoma and it is closely related to the progression of thyroid carcinoma.