CAJ | 학술논문

E-钙粘蛋白是一类细胞表面糖蛋白，在细胞-细胞间粘附中发挥重要作用，参与组织结构的维持。研究表明细胞粘附分子在肿瘤的发生、发展、侵袭和转移中起着重要作用，已成为肿瘤转移分子机制研究的重要课题之一。既往研究认为 E-钙粘蛋白是一种肿瘤抑制因子，然而最近研究表明 E-钙粘蛋白的异常表达与肿瘤发生、侵袭转移密切相关，提示 E-钙粘蛋白不仅有抑癌作用，还具有促癌作用。而肿瘤的侵袭转移是癌症患者死亡的主要原因，本文将对 E-钙粘蛋白在肿瘤发生及转移中的作用机制进行综述，以期为肿瘤的临床治疗提供更多的理论依据。
E-개점단백시일류세포표면당단백，재세포-세포간점부중발휘중요작용，삼여조직결구적유지。연구표명세포점부분자재종류적발생、발전、침습화전이중기착중요작용，이성위종류전이분자궤제연구적중요과제지일。기왕연구인위 E-개점단백시일충종류억제인자，연이최근연구표명 E-개점단백적이상표체여종류발생、침습전이밀절상관，제시 E-개점단백불부유억암작용，환구유촉암작용。이종류적침습전이시암증환자사망적주요원인，본문장대 E-개점단백재종류발생급전이중적작용궤제진행종술，이기위종류적림상치료제공경다적이론의거。
E-cadherin is a cell surface glycoprotein. It plays an important role in intercellular adhesion, and participates in the maintenance of the organizational structure. Research results have shown that the cell adhesion molecule has a very important role in tumor development, invasion and metastasis process, and has become one of the important topics in the re-search of tumor metastasis molecular mechanism. Previous studies suggested that E-cadherin is a tumor suppressor. However, recent studies have shown that the abnormal expression of E-cadherin is closely related with the tumor development, invasion and metastasis, indicating that E-cadherin is not only a tumor suppressor, but also has a role of tumor promotion. Tumor in-vasion and metastasis is the leading cause of death for cancer patients. Therefore, this paper summarized the role of E-cadherin in tumorigenesis and metastasis mechanism, so as to provide more theoretical basis for clinical treatment of tumors.