CAJ | 학술논문

骨修复是一个复杂过程，需要细胞与各种生长因子的协同作用。生长因子是一类通过与特异的、高亲和的细胞膜受体结合，调节细胞生长与其他细胞功能等多效应的小分子多肽类物质。重组生长因子是利用基因工程技术生产的生长因子产品。由于生长因子在骨修复过程中的重要作用以及传统骨移植方法暴露出的一些不良反应和并发症问题，用重组生长因子治疗骨缺损、骨不连以及重组生长因子在各种骨科手术中的应用越来越受到研究人员的重视。本文对重组人血小板衍生生长因子（rhPDGF）、重组人骨形成蛋白（rhBMPs）促骨修复的实验和临床研究以及其它重组生长因子的研究进展作综述。
골수복시일개복잡과정，수요세포여각충생장인자적협동작용。생장인자시일류통과여특이적、고친화적세포막수체결합，조절세포생장여기타세포공능등다효응적소분자다태류물질。중조생장인자시이용기인공정기술생산적생장인자산품。유우생장인자재골수복과정중적중요작용이급전통골이식방법폭로출적일사불량반응화병발증문제，용중조생장인자치료골결손、골불련이급중조생장인자재각충골과수술중적응용월래월수도연구인원적중시。본문대중조인혈소판연생생장인자（rhPDGF）、중조인골형성단백（rhBMPs）촉골수복적실험화림상연구이급기타중조생장인자적연구진전작종술。
Proper bone healing involves a complex interaction of cells and growth factors (GF). GF are very small polypeptides which can bind to target cell receptors to effect cell growth and other cell function. Recombinant growth factors are GF products produced by genetic engineering technology. Since GF play an important role in bone repair and the adverse reactions or complications due to bone grafts,applications of recombinant GF are being increasingly advocated in non-unions and orthopedic practices. In this paper,the use of rhPDGF,rhBMPs and other different recombinant GF for bone repair stimulation is summarized in experimental research and clinical applications.