CAJ | 학술논문

目的：探讨内皮素（ET）和一氧化氮（NO）在阻塞性睡眠呼吸暂停低通气综合征（OSAHS）合并高血压发病中的作用。方法：对53例阻塞性睡眠呼吸暂停低通气综合征（OSAHS）合并高血压和48例OSAHS血压正常者手术治疗，手术前后测量血压、多导睡眠图仪、血浆ET和血清NO，同时取19例健康人作对照。结果：（1）OS-AHS患者的收缩压和舒张压均与最低血氧饱和度（SaO2）和一氧化氮（NO）呈负相关，与呼吸暂停低通气指数（AHI）和ET呈正相关（P＜0.05）。（2）OSAHS高血压组和OSAHS血压正常组的AHI、ET均高于健康对照组，最低SaO2、NO均低于健康对照组（P＜0.01）。OSAHS高血压组的AHI、ET高于血压正常组，最低SaO2、NO低于血压正常组（P＜0.01）。（3）OSAHS高血压组手术后与手术前比较，收缩压、舒张压、AHI、ET均降低，最低SaO2和NO升高（P＜0.01）。OSAHS血压正常组手术后与手术前比较，AHI、ET均降低，最低SaO2和NO升高（P＜0.01）。结论：ET和NO在OSAHS患者并发高血压的过程中发挥一定作用。
목적：탐토내피소（ET）화일양화담（NO）재조새성수면호흡잠정저통기종합정（OSAHS）합병고혈압발병중적작용。방법：대53례조새성수면호흡잠정저통기종합정（OSAHS）합병고혈압화48례OSAHS혈압정상자수술치료，수술전후측량혈압、다도수면도의、혈장ET화혈청NO，동시취19례건강인작대조。결과：（1）OS-AHS환자적수축압화서장압균여최저혈양포화도（SaO2）화일양화담（NO）정부상관，여호흡잠정저통기지수（AHI）화ET정정상관（P＜0.05）。（2）OSAHS고혈압조화OSAHS혈압정상조적AHI、ET균고우건강대조조，최저SaO2、NO균저우건강대조조（P＜0.01）。OSAHS고혈압조적AHI、ET고우혈압정상조，최저SaO2、NO저우혈압정상조（P＜0.01）。（3）OSAHS고혈압조수술후여수술전비교，수축압、서장압、AHI、ET균강저，최저SaO2화NO승고（P＜0.01）。OSAHS혈압정상조수술후여수술전비교，AHI、ET균강저，최저SaO2화NO승고（P＜0.01）。결론：ET화NO재OSAHS환자병발고혈압적과정중발휘일정작용。
Aim:To explore the role of endothelin (ET)and nitric oxide (NO)in the pathogenesis of hypertension in obstructive sleep apnea hypopnea syndrome (OSAHS ).Methods:The levels of blood pressure,plasma ET,serum NO and polysomnography (PSG)parameters in 53 OSAHS patients accom-panied hypertension and 48 normotensive OSAHS patients were measured,before and after operation. Nineteen healthy subjects were used as healthy control.Results:(1 )In OSAHS patients,the systolic pressure and diastolic pressure negatively correlated with the lowest SaO2 and NO;positively correlated with apnea hypopnea index (AHI)and ET (P<0.05).(2)Compared with healthy people,AHI and ET were higher,while the lowest SaO2 and NO were lower in OSAHS patients with or without hyperten-sion(P<0.01).AHI and ET in OSAHS patients with hypertension were higher than those in OSAHS pa-tients without hypertension,while the lowest SaO2 and NO in OSAHS patients with hypertension were low-er than that in OSAHS patients without hypertension(P<0.01 ).3.In OSAHS patients with hyperten-sion,the systolic pressure,diastolic pressure,AHI and ET decreased after operation,while the lowest SaO2 and NO increased after operation (P<0.01 ).In OSAHS patients without hypertension,AHI and ET decreased after operation,while the lowest SaO2 and NO increased after operation (P<0.01).Con-clusion:ET and NO may play a role in the pathogenesis of OSAHS-induced hypertension.