CAJ | 학술논문

制备羊毛角蛋白/羟甲基纤维素钠共混载药膜，并考察其体外释药性能。采用溶液共混浇铸成膜法，以奥硝唑为模型药物制备载药膜，模拟人体血液环境，通过原料配比、变性剂用量、药物用量、pH 值单因素对比试验考察体外释药性能，结果表明：羊毛角蛋白/羟甲基纤维素钠质量比6040、戊二醛用量0.1%、反应时间1小时、温度37℃条件下制备的共混载药膜，具有良好的药物缓释作用和 pH 值敏感性。载药膜致密均匀，扫描电镜显示成膜状态良好，贮存6个月，外观形态及释药性基本不变。
제비양모각단백/간갑기섬유소납공혼재약막，병고찰기체외석약성능。채용용액공혼요주성막법，이오초서위모형약물제비재약막，모의인체혈액배경，통과원료배비、변성제용량、약물용량、pH 치단인소대비시험고찰체외석약성능，결과표명：양모각단백/간갑기섬유소납질량비6040、무이철용량0.1%、반응시간1소시、온도37℃조건하제비적공혼재약막，구유량호적약물완석작용화 pH 치민감성。재약막치밀균균，소묘전경현시성막상태량호，저존6개월，외관형태급석약성기본불변。
To prepare wool keratin/hydroxymethyl cellulose sodium blend membrane carrying drug and investigate its release property in vitro.The drug-loaded membrane was prepared by solution blending method using ornidazole as a model drug .The single factor contrast tests of raw material ra-tio,the amount of denaturant,drug dosage and pH value on drug release property were investigated through simulating the environment of human blood.results showed that:the drug-loaded membrane had an obviously sustained release effect and pH sensitive function under the optimal condition(kera-tin/CMCNa ratio 50 50;10% glutaraldehyde;reaction time 1 h;37 ℃).The drug-loaded membrane was dense and uniform,SEM images showed that it was in good condition.while stored for six months,morphology and drug release property remained essentially unchanged.