中国医师杂志
中國醫師雜誌
중국의사잡지
JOURNAL OF CHINESE PHYSICIAN
2014年
5期
612-615
,共4页
痛风%高尿酸血症%甲状腺激素类/血液%瘦素/血液
痛風%高尿痠血癥%甲狀腺激素類/血液%瘦素/血液
통풍%고뇨산혈증%갑상선격소류/혈액%수소/혈액
Gout%Hyperuricemia%Thyroid hormones/blood%Leptin/blood
目的 探讨痛风/高尿酸血症(HUA)患者血清甲状腺激素及瘦素的变化.方法 选取2011年3月至2011年8月在天津医科大学代谢病医院痛风专科住院的原发性痛风96例(男87例,女9例)及HUA患者65例(男30例、女35例)及同期在体检中心健康体检者59例(男36例、女23例).测定(1)血生化指标.(2)甲状腺功能.(3)空腹血糖(FPG)、空腹胰岛素(FINS),空腹瘦素.结果 (1)痛风组和HUA组的亚临床甲减检出率分别为7.29％、15.38％,明显高于正常对照组(0).(2)痛风及HUA组BMI、SBP、TG、总胆固醇(CHO)、促甲状腺激素(TSH)、FINS、胰岛素抵抗指数(HOMA-IR)、瘦素水平显著高于对照组,而游离甲状腺素(FT4)低于对照组(P＜0.05).(3)以TSH为因变量,以性别、年龄、BMI、血清尿酸(SUA)、肌酐清除率(Ccr)、FT4为自变量作多元线性回归分析显示:女性、年龄、BMI、SUA、FT4、HOMA-IR、瘦素进入回归方程(β=-0.27、0.832、0.946、0.198、-0.942、0.895、0.650).结论 原发性痛风/HUA患者亚临床甲减检出率明显升高,且女性高于男性.女性、年龄、BMI、SUA、FT4、HOMA-IR、瘦素是TSH升高的独立危险因素.胰岛素抵抗明显,瘦素水平高的痛风/高尿酸血症患者发生甲状腺功能低下的几率增加.
目的 探討痛風/高尿痠血癥(HUA)患者血清甲狀腺激素及瘦素的變化.方法 選取2011年3月至2011年8月在天津醫科大學代謝病醫院痛風專科住院的原髮性痛風96例(男87例,女9例)及HUA患者65例(男30例、女35例)及同期在體檢中心健康體檢者59例(男36例、女23例).測定(1)血生化指標.(2)甲狀腺功能.(3)空腹血糖(FPG)、空腹胰島素(FINS),空腹瘦素.結果 (1)痛風組和HUA組的亞臨床甲減檢齣率分彆為7.29％、15.38％,明顯高于正常對照組(0).(2)痛風及HUA組BMI、SBP、TG、總膽固醇(CHO)、促甲狀腺激素(TSH)、FINS、胰島素牴抗指數(HOMA-IR)、瘦素水平顯著高于對照組,而遊離甲狀腺素(FT4)低于對照組(P＜0.05).(3)以TSH為因變量,以性彆、年齡、BMI、血清尿痠(SUA)、肌酐清除率(Ccr)、FT4為自變量作多元線性迴歸分析顯示:女性、年齡、BMI、SUA、FT4、HOMA-IR、瘦素進入迴歸方程(β=-0.27、0.832、0.946、0.198、-0.942、0.895、0.650).結論 原髮性痛風/HUA患者亞臨床甲減檢齣率明顯升高,且女性高于男性.女性、年齡、BMI、SUA、FT4、HOMA-IR、瘦素是TSH升高的獨立危險因素.胰島素牴抗明顯,瘦素水平高的痛風/高尿痠血癥患者髮生甲狀腺功能低下的幾率增加.
목적 탐토통풍/고뇨산혈증(HUA)환자혈청갑상선격소급수소적변화.방법 선취2011년3월지2011년8월재천진의과대학대사병의원통풍전과주원적원발성통풍96례(남87례,녀9례)급HUA환자65례(남30례、녀35례)급동기재체검중심건강체검자59례(남36례、녀23례).측정(1)혈생화지표.(2)갑상선공능.(3)공복혈당(FPG)、공복이도소(FINS),공복수소.결과 (1)통풍조화HUA조적아림상갑감검출솔분별위7.29％、15.38％,명현고우정상대조조(0).(2)통풍급HUA조BMI、SBP、TG、총담고순(CHO)、촉갑상선격소(TSH)、FINS、이도소저항지수(HOMA-IR)、수소수평현저고우대조조,이유리갑상선소(FT4)저우대조조(P＜0.05).(3)이TSH위인변량,이성별、년령、BMI、혈청뇨산(SUA)、기항청제솔(Ccr)、FT4위자변량작다원선성회귀분석현시:녀성、년령、BMI、SUA、FT4、HOMA-IR、수소진입회귀방정(β=-0.27、0.832、0.946、0.198、-0.942、0.895、0.650).결론 원발성통풍/HUA환자아림상갑감검출솔명현승고,차녀성고우남성.녀성、년령、BMI、SUA、FT4、HOMA-IR、수소시TSH승고적독립위험인소.이도소저항명현,수소수평고적통풍/고뇨산혈증환자발생갑상선공능저하적궤솔증가.
Objective To explore the change of thyroid hormones and leptin at hyperuricemia (HUA)/gout.Methods A total of 96 primary gouts,65 HUAs,and 59 healthy examiners was selected.Height,weight,blood pressure,renal function,serum uric acid(SUA),glucose,lipid profiles,insulin,thyroid hormones were measured after an overnight fast.Results (1) The prevalence of subhypothyriodism at gout and HUA was 7.29％ and 15.38％,respectively.They were higher than that at healthy subjects.(2) Body mass index (BMI),systolic blood pressure (SBP),triglyceride (TG),cholesterol (CHO),thyroid stimulating hormone (TSH),fasting insulin (FINS),homeostasis model assessment of insulin resistance (HOMA-IR),and serum leptin level were increased remarkably at gout/hyperuricemia relative to control group,whereas,free thyroid hormone (FT4) was decreased.(4) In the gout and hyperuricemia groups,TSH was used as the dependent variable for the linear multivariate regression analysis,the results showed that sex,age,BMI,SUA,FT4,HOMA-IR,and Leptin were included in the regression equation of TSH (βwere-0.27,0.832,0.946,0.198,-0.942,0.895,and 0.650,respectively).Conclusions The prevalence of subhypothyroidism in primary gout/hyperuricemia was increased.Female,age,BMI,SUA,FT4,HOMA-IR,and leptin were the independent risk factors.Insulin resistant and leptin played the media roles in the gout/HUA and hypothyroidism.
