CAJ | 학술논문

目的观察对血糖控制不佳的超重初发糖尿病患者分别应用盐酸二甲双胍、利拉鲁肽进行降糖治疗后血糖变化的情况.方法将44例血糖控制不佳的超重初发2型糖尿病患者随机分为对照组、利拉鲁肽组及盐酸二甲双胍组,分别给予饮食和运动控制、利拉鲁肽皮下注射以及盐酸二甲双胍口服治疗等措施,观察时间为12周,对比治疗前、后患者的体质量指数(BMI)、空腹血糖(FBG)及餐后2h血糖(2 hPBG)、糖化血红蛋白(HbA1c)浓度.结果治疗后利拉鲁肽组和盐酸二甲双胍组患者的FBG、2 hPBG及HbA1c较治疗前均有降低,且与对照组治疗后比较,差异均有统计学意义(P均＜0.05);利拉鲁肽组的BMI[(24.61 ±3.47) kg/m2]较对照组[(25.37±4.70) kg/m2]明显降低,差异有统计学意义(P＜0.05);利拉鲁肽组的2 hPBG[(7.13±3.85) mmol/L]比盐酸二甲双胍组[(8.03±4.33) mmol/L]明显降低,差异有统计学意义(P＜0.05);盐酸二甲双胍组的FBG[(6.31±3.45) mmol/L]和利拉鲁肽组[(6.98±2.97) mmoL/L]相比有降低,但差异无统计学意义(P＞0.05).结论利拉鲁肽和盐酸二甲双胍片均可有效的降低超重糖尿病患者体质量指数及血糖,利拉鲁肽较盐酸二甲双胍片能更加明显的降低餐后血糖及患者体质量指数.
목적 관찰대혈당공제불가적초중초발당뇨병환자분별응용염산이갑쌍고、리랍로태진행강당치료후혈당변화적정황.방법 장44례혈당공제불가적초중초발2형당뇨병환자수궤분위대조조、리랍로태조급염산이갑쌍고조,분별급여음식화운동공제、리랍로태피하주사이급염산이갑쌍고구복치료등조시,관찰시간위12주,대비치료전、후환자적체질량지수(BMI)、공복혈당(FBG)급찬후2h혈당(2 hPBG)、당화혈홍단백(HbA1c)농도.결과 치료후리랍로태조화염산이갑쌍고조환자적FBG、2 hPBG급HbA1c교치료전균유강저,차여대조조치료후비교,차이균유통계학의의(P균＜0.05);리랍로태조적BMI[(24.61 ±3.47) kg/m2]교대조조[(25.37±4.70) kg/m2]명현강저,차이유통계학의의(P＜0.05);리랍로태조적2 hPBG[(7.13±3.85) mmol/L]비염산이갑쌍고조[(8.03±4.33) mmol/L]명현강저,차이유통계학의의(P＜0.05);염산이갑쌍고조적FBG[(6.31±3.45) mmol/L]화리랍로태조[(6.98±2.97) mmoL/L]상비유강저,단차이무통계학의의(P＞0.05).결론 리랍로태화염산이갑쌍고편균가유효적강저초중당뇨병환자체질량지수급혈당,리랍로태교염산이갑쌍고편능경가명현적강저찬후혈당급환자체질량지수.
Objective To investigate the effect of liraglutide and metformin hydrochioride on overweight diabetic patients because of poor glycemic control.Methods Forty-four overweight patients with poor glycemic control were randomly divided to the control group,the liraglutide group and the metformin hydrochioride group.Patients in control group were given diet and exercise control,in liraglutide group and the metformin hydrochioride group were given subcutaneous injection liraglutide,metformin hydrochioride oral treatment respectively for 12 weeks.Body mass index(BMI),fasting blood glucose (FBG),2-hour postprandial blood glucose (2 hPBG) and glycosylated hemoglobin (HbA1c) were measured.Results Compared with pretreatment,FBG,2 hPBG and HbA1c of patients in liraglutide group and metformin hydrochioride group were lower after treatment,and there was significant difference between the two group and the control group after treatment(P ＜ 0.05).BMI of patients in liraglutide group was (24.61 ± 3.47) kg/m2,lower than of the control group((25.37 ± 4.70) kg/m2,P ＜ 0.05).2 hPBG of patients in the liraglutide group was (7.13 ± 3.85)mtmol/L,lower than that of the metformin hydrochioride group ((8.03 ± 4.33) mtmol/L,P ＜ 0.05).FBG level in metformin hydrochioride group ((6.31 ± 3.45) mmol/L) was lower than that of the liraglutide group ((6.98±2.97) mmol/L),but the difference was not statistically significant(P ＞ 0.05).Conclusion Liraglutide and metformin hydrochioride treatment can effectively reduce weight and blood sugar of the overweight diabetics.The effect of liraglutide to reduce postprandial blood glucose and weight of the patient is more significant than of metformin hydrochioride.