CAJ | 학술논문

目的：分析以肿瘤热为主要表现的复发难治多发性骨髓瘤（RRMM）患者的临床特点、治疗和预后。方法：2006年1月至2013年5月我院血液科收治的4例以肿瘤热为主要表现的RRMM患者。对4例患者均进行了详尽的体格检查和辅助检查，无感染等非骨髓瘤性发热的证据，正规、足疗程的抗感染治疗无效，应用退热药物、激素治疗有效。同时MM相关检查均提示疾病进展，给予抗骨髓瘤治疗。结果：经过抗骨髓瘤治疗，2例治疗有效，体温降至正常；2例治疗效果不佳，因并发症死亡。结论：复发难治多发性骨髓瘤合并肿瘤热与疾病进展、耐药、预后不良相关。早期识别可以避免抗生素的过度使用以及药物相关不良反应发生。
목적：분석이종류열위주요표현적복발난치다발성골수류（RRMM）환자적림상특점、치료화예후。방법：2006년1월지2013년5월아원혈액과수치적4례이종류열위주요표현적RRMM환자。대4례환자균진행료상진적체격검사화보조검사，무감염등비골수류성발열적증거，정규、족료정적항감염치료무효，응용퇴열약물、격소치료유효。동시MM상관검사균제시질병진전，급여항골수류치료。결과：경과항골수류치료，2례치료유효，체온강지정상；2례치료효과불가，인병발증사망。결론：복발난치다발성골수류합병종류열여질병진전、내약、예후불량상관。조기식별가이피면항생소적과도사용이급약물상관불량반응발생。
Objective: To analyze the clinical characteristics、treatment and prognosis of relapsed/refractory multiple myeloma complicated with neoplastic fever. Methods: Four patients with relapsed/refractory MM complicated with neoplastic fever received careful physical examination and assistant investigation in our hospital from January 2006 to Octorber 2013, and standard anti-infective therapy was not used due to no infection evidence. Use of antipyretic and corticosteroid were effective. The examination of MM showed progressive disease and chemotherapy for them were used. Results:Of the four patients,two had a partial response(PR),and the temperature return to normal;the other two got poor efficacy and died of complications. Conclusion: Neoplastic fever of RRMM is related to progressive disease、drug resistance and poor prognosis. Timely recognition to neoplastic fever may avoid overuse of antibiotics and the occurrence of adverse drug event.