CAJ | 학술논문

根管治疗中使用的充填材料因其会长期存留于口腔内，其安全性历来受到人们的关注，其生物相容性的好坏直接影响了根充的质量及根尖周组织的修复反应。生物相容性检测包括组织学、细胞学、基因及分子学等不同水平的生物学评价，目前细胞毒性和基因毒性实验已成为其中重要指标。本文就近年来有关常用根管充填材料细胞毒性和基因毒性的研究进展作一综述。
근관치료중사용적충전재료인기회장기존류우구강내，기안전성력래수도인문적관주，기생물상용성적호배직접영향료근충적질량급근첨주조직적수복반응。생물상용성검측포괄조직학、세포학、기인급분자학등불동수평적생물학평개，목전세포독성화기인독성실험이성위기중중요지표。본문취근년래유관상용근관충전재료세포독성화기인독성적연구진전작일종술。
The?filling?materials?utilized?in?root?canal?therapy?have?a?long-term?retention?in?the?oral?cavity.?Safety?and?biocompatibility?of?the?filing?materials?always?draw?people’s?attention.?The?biocompatibility?of?these?materials?has?a?direct?impact?on?the?quality?of?root?canal?filling?and?periapical?tissue?repair?response.?Biocompatibility?tests,?including?histology,?cytology,?molecular?genetics,?and?biological?evaluation?of?different?levels,?cytotoxicity,?and?genotoxicity?of?materials,?have?been?successfully?utilized?to?evaluate?the?biocompatibility?of?the?materials.?This?study?is?a?review?about?the?cytotoxicity?and?genotoxicity?of?root?canal?filling?materials.