中国癌症杂志
中國癌癥雜誌
중국암증잡지
CHINA ONCOLOGY
2013年
7期
519-523
,共5页
吴又明%丁彦青%李纳%王金生%郭周庆%冷雷%黄东
吳又明%丁彥青%李納%王金生%郭週慶%冷雷%黃東
오우명%정언청%리납%왕금생%곽주경%랭뢰%황동
锯齿状腺瘤%传统腺瘤%端粒酶%P53%Ki-67
鋸齒狀腺瘤%傳統腺瘤%耑粒酶%P53%Ki-67
거치상선류%전통선류%단립매%P53%Ki-67
Serrated adenoma%Traditional adenoma%Telomerase%p53%Ki-67
背景与目的：结直肠锯齿状腺瘤(serrated adenoma，SA)是2000年被WHO正式命名为独立的一种疾病，与传统腺瘤(traditional adenoma，TA)和结直肠癌(colorectal carcinoma，CRC)比较有其独特的性质。本研究通过对锯齿状腺瘤、传统腺瘤和结直肠癌组织中端粒酶、p53及Ki-67的免疫组化表达比较，探讨锯齿状腺瘤与普通腺瘤的恶性潜能异同及与大肠腺癌的关系。方法：运用免疫组化MaxVision法对37例锯齿状腺瘤、36例传统腺瘤，34例结直肠癌组织标本进行端粒酶、p53及Ki-67检测。结果：端粒酶在锯齿状腺瘤、传统腺瘤和结直肠癌组间差异有统计学意义(P<0.05)，结直肠癌组阳性率高于锯齿状腺瘤组(P<0.05)，锯齿状腺瘤组高于传统腺瘤组(P<0.01)；Ki-67在锯齿状腺瘤与传统腺瘤两组差异无统计学意义(P>0.05)，结直肠癌组的阳性率则明显高于锯齿状腺瘤和传统腺瘤组(P<0.01)；结直肠癌组p53阳性率高于传统腺瘤组(P<0.01)，传统腺瘤组高于锯齿状腺瘤组(P<0.01)。结论：端粒酶、p53及Ki-67检测显示：锯齿状腺瘤是一种具有较强活性的腺瘤，端粒酶的激活可能在其癌变过程中起一定作用。
揹景與目的：結直腸鋸齒狀腺瘤(serrated adenoma，SA)是2000年被WHO正式命名為獨立的一種疾病，與傳統腺瘤(traditional adenoma，TA)和結直腸癌(colorectal carcinoma，CRC)比較有其獨特的性質。本研究通過對鋸齒狀腺瘤、傳統腺瘤和結直腸癌組織中耑粒酶、p53及Ki-67的免疫組化錶達比較，探討鋸齒狀腺瘤與普通腺瘤的噁性潛能異同及與大腸腺癌的關繫。方法：運用免疫組化MaxVision法對37例鋸齒狀腺瘤、36例傳統腺瘤，34例結直腸癌組織標本進行耑粒酶、p53及Ki-67檢測。結果：耑粒酶在鋸齒狀腺瘤、傳統腺瘤和結直腸癌組間差異有統計學意義(P<0.05)，結直腸癌組暘性率高于鋸齒狀腺瘤組(P<0.05)，鋸齒狀腺瘤組高于傳統腺瘤組(P<0.01)；Ki-67在鋸齒狀腺瘤與傳統腺瘤兩組差異無統計學意義(P>0.05)，結直腸癌組的暘性率則明顯高于鋸齒狀腺瘤和傳統腺瘤組(P<0.01)；結直腸癌組p53暘性率高于傳統腺瘤組(P<0.01)，傳統腺瘤組高于鋸齒狀腺瘤組(P<0.01)。結論：耑粒酶、p53及Ki-67檢測顯示：鋸齒狀腺瘤是一種具有較彊活性的腺瘤，耑粒酶的激活可能在其癌變過程中起一定作用。
배경여목적：결직장거치상선류(serrated adenoma，SA)시2000년피WHO정식명명위독립적일충질병，여전통선류(traditional adenoma，TA)화결직장암(colorectal carcinoma，CRC)비교유기독특적성질。본연구통과대거치상선류、전통선류화결직장암조직중단립매、p53급Ki-67적면역조화표체비교，탐토거치상선류여보통선류적악성잠능이동급여대장선암적관계。방법：운용면역조화MaxVision법대37례거치상선류、36례전통선류，34례결직장암조직표본진행단립매、p53급Ki-67검측。결과：단립매재거치상선류、전통선류화결직장암조간차이유통계학의의(P<0.05)，결직장암조양성솔고우거치상선류조(P<0.05)，거치상선류조고우전통선류조(P<0.01)；Ki-67재거치상선류여전통선류량조차이무통계학의의(P>0.05)，결직장암조적양성솔칙명현고우거치상선류화전통선류조(P<0.01)；결직장암조p53양성솔고우전통선류조(P<0.01)，전통선류조고우거치상선류조(P<0.01)。결론：단립매、p53급Ki-67검측현시：거치상선류시일충구유교강활성적선류，단립매적격활가능재기암변과정중기일정작용。
Background and purpose:Colorectal serrated adenoma (SA) was ofifcially named in 2000 by the WHO as a separate disease, with unique properties compared with traditional adenoma (TA), and its relationship with colorectal cancer (CRC) is very concerned. This study was to analyze and compare the telomerase, p53 and Ki-67 immunohistochemical expression on the tissues of SA, TA and CRC. Methods:Immunohistochemistry was adopted to analyze the expression of telomerase, p53, and Ki-67 in 37 cases of SA, 36 cases of TA and 34 cases of CRC. Results:The p53-positive percentage of SA was signiifcantly lower than that of TA (P<0.01), and the p53-positive percentage of TA was signiifcantly lower than that of CRC (P<0.01). No signiifcant difference of Ki-67 expression was found between SA and TA, and the Ki-67-positive percentage of SA and TA was lower than that of CRC (P<0.01). The telomerase-positive percentage of TA was signiifcantly lower than that of SA (P<0.01), and the telomerase-positive percentage of SA was signiifcantly lower than that of CRC (P<0.05). Conclusion:Telomerase, P53, and Ki-67 immunohisto chemical analysis indicated that SA is a kind of proliferative adenoma, and telomerase activation may play a role in the cancer process.
