CAJ | 학술논문

背景与目的：上皮钙黏蛋白(E-cadherin，E-cad)作为一种关键的结构蛋白对正常的细胞极性、上皮形态和细胞分化非常重要。最近有研究表明E-cad基因启动子区域-160 C/A基因多态性与鼻咽癌(nasopharyngeal carcinoma，NPC)的易感性有关。本研究旨在评价中国汉族人群中NPC危险性和E-cad基因启动子-160 C/A位点多态性的关系。方法：选取303例明确诊断为NPC的患者为实验组，同时选取318位健康志愿者为对照组。采用TaqMan探针技术检测启动子区域-160 C/A位点的单核苷酸多态性。结果：按性别和年龄调整后，实验组E-cad基因启动子-160 C/A位点A/A基因型危险性显著高于对照组(调整后OR=2.09，95%CI：1.03~4.22，P=0.04)。按性别分层后，女性NPC患者中A/A基因型危险性显著高于对照组(OR=7.57，95%CI：1.57~36.47，P=0.012)。此外，与NPC患者中男性A/A基因型比对，女性A/A基因型具有更高的患病风险(OR=2.66，95%CI：1.14~6.20，P=0.024)。结论：E-cad基因启动子-160 C/A位点的A/A基因型是中国汉族人群患NPC的危险因素之一，尤其对于女性患者尤为显著。
배경여목적：상피개점단백(E-cadherin，E-cad)작위일충관건적결구단백대정상적세포겁성、상피형태화세포분화비상중요。최근유연구표명E-cad기인계동자구역-160 C/A기인다태성여비인암(nasopharyngeal carcinoma，NPC)적역감성유관。본연구지재평개중국한족인군중NPC위험성화E-cad기인계동자-160 C/A위점다태성적관계。방법：선취303례명학진단위NPC적환자위실험조，동시선취318위건강지원자위대조조。채용TaqMan탐침기술검측계동자구역-160 C/A위점적단핵감산다태성。결과：안성별화년령조정후，실험조E-cad기인계동자-160 C/A위점A/A기인형위험성현저고우대조조(조정후OR=2.09，95%CI：1.03~4.22，P=0.04)。안성별분층후，녀성NPC환자중A/A기인형위험성현저고우대조조(OR=7.57，95%CI：1.57~36.47，P=0.012)。차외，여NPC환자중남성A/A기인형비대，녀성A/A기인형구유경고적환병풍험(OR=2.66，95%CI：1.14~6.20，P=0.024)。결론：E-cad기인계동자-160 C/A위점적A/A기인형시중국한족인군환NPC적위험인소지일，우기대우녀성환자우위현저。
Background and purpose:The E-cadherin as a pivotal structural protein is important for cellular polarity and maintainance of normal tissue morphology and cellular differentiation. Recently some study investigated the impact of the C/A genetic polymorphism at-160 from the site of the E-cadherin gene promoter on susceptibility in NPC. To evaluate the association of the E-cadherin gene promoter-160 C/A single nucleotide polymorphism (SNP) and nasopharyngeal carcinoma risk in a Chinese population, we designed a hospital-based case-control study. Methods:Subjects included in this study were 303 patients deifnitely diagnosed with NPC, and 318 matched healthy controls. We used TaqMan Probe method for analyzing polymorphism. Results:The A/A genotype was associated with increased risk of NPC after being adjusted for age and gender (adjusted OR=2.09, 95%CI:1.03-4.22, P=0.04). When 2 gender groups were analysed respectively, female group with A/A genotypes showed a higher risk (OR=7.57, 95%CI:1.57-36.47, P=0.012). Besides, among NPC patients compared with males A/A genotype, females with A/A genotype had a signiifcant risk(OR=2.66, 95%CI:1.14-6.20, P=0.024). Conclusion:The A/A genotype of E-cadherin promoter-160 C/A might be genetic risk factor for NPC, especially female patients.