CAJ | 학술논문

抗菌肽是一类具有抗菌、抗病毒、抗肿瘤等生物活性的小分子多肽，与传统抗生素相比，不易产生耐药性；但因其毒性强、稳定性差、合成成本高等原因，抗菌肽还不能广泛应用于临床。为此，药物学家们对其进行了结构改造，获得了高活性、低毒性的抗菌肽。该文综述了抗菌肽分子设计的研究进展及发展方向。
항균태시일류구유항균、항병독、항종류등생물활성적소분자다태，여전통항생소상비，불역산생내약성；단인기독성강、은정성차、합성성본고등원인，항균태환불능엄범응용우림상。위차，약물학가문대기진행료결구개조，획득료고활성、저독성적항균태。해문종술료항균태분자설계적연구진전급발전방향。
Antimicrobial peptides ( AMPs) are a kind of micromolecular peptides with antibacterial , antivirus and anti-tumor activities.Unlike conventional antibiotics , acquisition of resistance by a sensitive microbial strain against AMPs is surprisingly improbable .AMPs are not widely used clinically due to their toxicity , susceptibility to proteolysis and high manufacturing cost .Researchers have obtained some AMPs with high activity and low toxicity by structure modifications . The molecular design of AMPs as well as their development in the future are reviewed .