CAJ | 학술논문

目的探讨游离循环DNA（cf-DNA）以及联合应用直肠指诊（DRE）和经直肠超声（TRUS）检查对前列腺癌的诊断价值。方法对93例可疑前列腺癌患者进行DRE、cf-DNA、TRUS检查并与术后病理结果对照，比较三种检查方法单独应用、两者联合应用及三者联合应用对前列腺癌的诊断价值。结果前列腺癌、前列腺良性病变和对照组血清cf-DNA的浓度分别是中位数1223.2 ng/ml、153.2 ng/ml和118.3 ng/ml，三者依次减低，差异有统计学意义（P＜0.001）；cf-DNA＋TRUS+DRE的联合检测方法的敏感性为90.6％，均高于cf-DNA、TRUS和DRE，差异有统计学意义（P＜0.05）；联合检测特异性也高于cf-DNA、TRUS和DRE，差异有统计学意义（P＜0.05），但与TRUS特异性差异无统计学意义（P>0.05）。结论联合应用DRE、cf-DNA、TRUS对提高前列腺癌的诊断具有重要临床价值。
목적탐토유리순배DNA（cf-DNA）이급연합응용직장지진（DRE）화경직장초성（TRUS）검사대전렬선암적진단개치。방법대93례가의전렬선암환자진행DRE、cf-DNA、TRUS검사병여술후병리결과대조，비교삼충검사방법단독응용、량자연합응용급삼자연합응용대전렬선암적진단개치。결과전렬선암、전렬선량성병변화대조조혈청cf-DNA적농도분별시중위수1223.2 ng/ml、153.2 ng/ml화118.3 ng/ml，삼자의차감저，차이유통계학의의（P＜0.001）；cf-DNA＋TRUS+DRE적연합검측방법적민감성위90.6％，균고우cf-DNA、TRUS화DRE，차이유통계학의의（P＜0.05）；연합검측특이성야고우cf-DNA、TRUS화DRE，차이유통계학의의（P＜0.05），단여TRUS특이성차이무통계학의의（P>0.05）。결론연합응용DRE、cf-DNA、TRUS대제고전렬선암적진단구유중요림상개치。
Objective To investigate the diagnostic value of free circulating DNA (cf-DNA) and its combination with digital rectal examination (DRE), and transrectal ultrasound (TRUS) method for prostate cancer. Methods Ninty-three suspected patients of prostate cancer were all examined by DRE, cf-DNA and TRUS. The diagnostic value of the three methods alone, combination of the two and the combination diagnosis of the three were evaluated. Results The median concentration for prostate cancer group, non-prostate cancer group and healthy control group were 1223.2 ng/ml, 153.2 ng/ml and 118.3 ng/ml. There was significant difference among the three groups (P<0.001). The sensitivity for combined method of cf-DNA,TRUS and DRE was 90.6%, which was higher than that of cf-DNA, TRUS or DRE alone, which was statistically significant(P<0.05);the specificity of combined detection was also higher than that of cf-DNA and DRE, which was also significant (P<0.05), but not for TRUS. Conclusion The combined application of digital rectal examination, cf-DNA and transrectal ultrasonography is clinically important for prostate cancer diagnosis.