CAJ | 학술논문

目的探讨血尿酸对血透患者心血管疾病的影响．方法测定80例血透患者的血尿酸水平和其他实验室指标，并通过超声心动图测定左心室射血分数（LVEF），计算左心室心肌重量指数（LVMI），对血透患者血尿酸水平进行临床分析．结果血透患者按照血尿酸水平分为两组：高尿酸血症组和血尿酸正常组，两组患者在有/无高血压、发现高血压时间、血透前收缩压均有统计学差异（P＜0.05）；高尿酸血症组血尿酸、肌酐、甘油三酯、低密度脂蛋白胆固醇、C反应蛋白、脑钠肽、LVMI均高于血尿酸正常组（P＜0.05），血清白蛋白、前白蛋白、高密度脂蛋白胆固醇、LVEF均低于血尿酸正常组（P＜0.05）．80例血透患者血尿酸水平与血透前收缩压、血清肌酐、甘油三酯、低密度脂蛋白胆固醇、C反应蛋白、脑钠肽、LVMI均呈正相关（P＜0.05），与血清白蛋白、前白蛋白、高密度脂蛋白胆固醇、LVEF均呈负相关（P＜0.05）．结论高尿酸血症与血透患者心血管疾病的发生发展相关．
목적탐토혈뇨산대혈투환자심혈관질병적영향．방법측정80례혈투환자적혈뇨산수평화기타실험실지표，병통과초성심동도측정좌심실사혈분수（LVEF），계산좌심실심기중량지수（LVMI），대혈투환자혈뇨산수평진행림상분석．결과혈투환자안조혈뇨산수평분위량조：고뇨산혈증조화혈뇨산정상조，량조환자재유/무고혈압、발현고혈압시간、혈투전수축압균유통계학차이（P＜0.05）；고뇨산혈증조혈뇨산、기항、감유삼지、저밀도지단백담고순、C반응단백、뇌납태、LVMI균고우혈뇨산정상조（P＜0.05），혈청백단백、전백단백、고밀도지단백담고순、LVEF균저우혈뇨산정상조（P＜0.05）．80례혈투환자혈뇨산수평여혈투전수축압、혈청기항、감유삼지、저밀도지단백담고순、C반응단백、뇌납태、LVMI균정정상관（P＜0.05），여혈청백단백、전백단백、고밀도지단백담고순、LVEF균정부상관（P＜0.05）．결론고뇨산혈증여혈투환자심혈관질병적발생발전상관．
Objective To investigate the effect of serum uric acid (UA) on cardiovascular diseases in hemodialysis patients. Methods The serum level of uric acid and other laboratory indexes of 80 hemodialysis patients were detected,and the left ventricular mass index (LVMI) and left ventricular ejection fraction (LVEF) were detected by ultrasonic cardiography examination. Results According to the serum level of UA, the hemodialysis patients were divided into 2 groups:the group with high serum level of UA and the group with normal serum level of UA. There were significant differences (P<0.05) in hypertension history,the period of hypertension history, systolic blood pressure before hemodialysis between the two groups. The serum levels of UA,creatinine, triglyceride, low density lipoprotein cholesterol, C-reactive protein, brain natriuretic peptide and LVMI were significantly higher,while the serum levels of albumin,pre-albumin,high density lipoprotein cholesterol, LVEF were lower in the group with high serum level of UA than those in the group with normal high serum level of UA (P<0.05) . Furthermore, the serum levels of UA in 80 patients was positively correlated to systolic blood pressure before hemodialysis, serum creatinine, triglyceride, low density lipoprotein cholesterol, C-reactive protein, brain natriuretic peptide, and LVMI (P<0.05), while it was negatively correlated to serum albumin, pre-albumin, high density lipoprotein cholesterol and LVEF (P<0.05) . Conclusion High serum level of uric acid is associated with the onset of cardiovascular diseases in hemodialysis patients.