昆明医科大学学报
昆明醫科大學學報
곤명의과대학학보
Journal of Kunming Medical University
2013年
8期
84-87
,共4页
8-羟基脱氧鸟苷%糖尿病%胰岛功能受损%相关分析
8-羥基脫氧鳥苷%糖尿病%胰島功能受損%相關分析
8-간기탈양조감%당뇨병%이도공능수손%상관분석
8-hydroxyquinoline deoxyguanosine%Diabetes%Islet dysfunction%Correlation analysis
目的观察8-羟基脱氧鸟苷（8-OHdG）水平在不同糖代谢患者中的表达水平，探讨其与胰岛功能损害的相关关系．方法依据75 g葡萄糖耐量试验（OGTT）分为正常糖耐量（NGT）组30例，单纯糖耐量异常（IGT）组28例，2型糖尿病（T2DM）组28例，并设立健康对照组（healthy control，HC）30例，检测患者三酰甘油（TG）和总胆固醇（TC），糖化血红蛋白（HbA1c），空腹血糖（FBG），计算胰岛素抵抗指数，胰岛素及c肽曲线下面积（AUC），比较各组间差异，并分析8-OHdG与各指标的相关关系．结果除NGT组FBG值与HC组间无差异外，其它组各指标均高于HC组，差异有统计学意义（P＜0.01）；IGT组FBG、8-OHdG、HbA1C、HOMA-IR高于NGT组，差异有统计学意义（P＜0.01）；T2DM组FBG、8-OHdG、HbA1C、HOMA-IR高于IGT组．胰岛素AUC在NGT、IGT和T2DM组间无差异（P＞0.05）；8-OHdG与FBG、HbA1c、HOMA-IR、C肽AUC、胰岛素AUC均有相关性，相关系数依为0.704，0.713，0.665，0.825，0.653，差异均有统计学意义．结论8-OHdG水平能够反应胰岛功能受损的状态，可作为判断糖尿病患者胰岛功能的检测指标．
目的觀察8-羥基脫氧鳥苷（8-OHdG）水平在不同糖代謝患者中的錶達水平，探討其與胰島功能損害的相關關繫．方法依據75 g葡萄糖耐量試驗（OGTT）分為正常糖耐量（NGT）組30例，單純糖耐量異常（IGT）組28例，2型糖尿病（T2DM）組28例，併設立健康對照組（healthy control，HC）30例，檢測患者三酰甘油（TG）和總膽固醇（TC），糖化血紅蛋白（HbA1c），空腹血糖（FBG），計算胰島素牴抗指數，胰島素及c肽麯線下麵積（AUC），比較各組間差異，併分析8-OHdG與各指標的相關關繫．結果除NGT組FBG值與HC組間無差異外，其它組各指標均高于HC組，差異有統計學意義（P＜0.01）；IGT組FBG、8-OHdG、HbA1C、HOMA-IR高于NGT組，差異有統計學意義（P＜0.01）；T2DM組FBG、8-OHdG、HbA1C、HOMA-IR高于IGT組．胰島素AUC在NGT、IGT和T2DM組間無差異（P＞0.05）；8-OHdG與FBG、HbA1c、HOMA-IR、C肽AUC、胰島素AUC均有相關性，相關繫數依為0.704，0.713，0.665，0.825，0.653，差異均有統計學意義．結論8-OHdG水平能夠反應胰島功能受損的狀態，可作為判斷糖尿病患者胰島功能的檢測指標．
목적관찰8-간기탈양조감（8-OHdG）수평재불동당대사환자중적표체수평，탐토기여이도공능손해적상관관계．방법의거75 g포도당내량시험（OGTT）분위정상당내량（NGT）조30례，단순당내량이상（IGT）조28례，2형당뇨병（T2DM）조28례，병설립건강대조조（healthy control，HC）30례，검측환자삼선감유（TG）화총담고순（TC），당화혈홍단백（HbA1c），공복혈당（FBG），계산이도소저항지수，이도소급c태곡선하면적（AUC），비교각조간차이，병분석8-OHdG여각지표적상관관계．결과제NGT조FBG치여HC조간무차이외，기타조각지표균고우HC조，차이유통계학의의（P＜0.01）；IGT조FBG、8-OHdG、HbA1C、HOMA-IR고우NGT조，차이유통계학의의（P＜0.01）；T2DM조FBG、8-OHdG、HbA1C、HOMA-IR고우IGT조．이도소AUC재NGT、IGT화T2DM조간무차이（P＞0.05）；8-OHdG여FBG、HbA1c、HOMA-IR、C태AUC、이도소AUC균유상관성，상관계수의위0.704，0.713，0.665，0.825，0.653，차이균유통계학의의．결론8-OHdG수평능구반응이도공능수손적상태，가작위판단당뇨병환자이도공능적검측지표．
Objective To observe the expression levels of 8 - hydroxy-deoxyguanosine (8-OHdG) in patients with different glucose metabolism and its relationship with islet dysfunction.Methods Based on the 75 g oral glucose tolerance test (OGTT), the patients were divided into 3 groups: normal glucose tolerance (NGT) group (30 patients), isolated impaired glucose tolerance (IGT) group (28 patients), type 2 diabetes mellitus (T2DM) group (28 patients), and 30 healthy subjects were selected as the healthy control group (healthy control, HC) . The triglyceride (TG) and total cholesterol (TC), glycosylated hemoglobin (HbA1c), fasting blood glucose (FBG), insulin resistance index, insulin and c-peptide area under the curve (AUC) were detected, and compared between groups, and the correlation between 8-OHdG and these indexes was analyzed. Results There was no difference in FBG values between NGT group and HC group, the indicators of patients in other groups were higher than HC group,the difference was statistically significant (P<0.01). The values of FBG, 8-OHdG, HbA1C and HOMA-IR of patients in IGT group were higher than NGT group, the difference was statistically significant (P<0.01) . The values of FBG ,8-OHdG, HbA1C and HOMA-IR in T2DM group were higher than IGT group. There were no differences in insulin AUC between NGT group, IGT group and T2DM group (P> 0.05) . 8-OHdG was correlated with FBG, HbA1c, HOMA-IR, C peptide AUC, insulin AUC, and the correlation coefficients were 0.704, 0.713, 0.665, 0.825 and 0.653, respectively, the differences were statistically significant. Conclusions 8-OHdG levels can reflect the status of islet dysfunction,and can be used as an indicator of islet function for diabetic patients.
