CAJ | 학술논문

目前正在进行的卒中神经保护策略研究主要有白蛋白、镁和低温治疗等；一些有前景的神经保护剂如人参皂苷Rd（ginsenoside Rd，GSRd）、突触后膜密95蛋白阻断剂NA-1（a 20-amino acid peptide，Tat-NR2B9c）等的研究还在探索中。神经保护研究的30年经历了由高潮到低谷再到新高潮的发展阶段，而未来神经保护治疗的研究要取得更好的发展需注重：动物实验中的严格设计，研究对象应从龋齿动物向灵长类动物转化，评价方法由行为评估向影像学评估转变；而整体研究范式应扩展到血管神经网络。
목전정재진행적졸중신경보호책략연구주요유백단백、미화저온치료등；일사유전경적신경보호제여인삼조감Rd（ginsenoside Rd，GSRd）、돌촉후막밀95단백조단제NA-1（a 20-amino acid peptide，Tat-NR2B9c）등적연구환재탐색중。신경보호연구적30년경력료유고조도저곡재도신고조적발전계단，이미래신경보호치료적연구요취득경호적발전수주중：동물실험중적엄격설계，연구대상응종우치동물향령장류동물전화，평개방법유행위평고향영상학평고전변；이정체연구범식응확전도혈관신경망락。
Many ongoing studies of neuroprotective strategy of stroke include albumin, magnesium and cryotherapy therapy. There are also a number of promising neuroprotectants in preclinical development including ginsenoside Rd, NA-1 (Tat-NR2B9c), an inhibitor of postsynaptic density-95 protein etc. Thirty years' study of neuroprotective strategy of stroke experiences the development process from the peak to the trough then to new climax. However, to achieve better development, future research should focus on:conduct a strict design;the object of study should converse from dental caries animal to primate;the evaluation method should converse from behavioral assessment to radiographic evaluation;research paradigm should extend to vascular neural network.