CAJ | 학술논문

目的：探讨血细胞分析中的平均红细胞体积(MCV)，平均红细胞血红蛋白量(MCH)，并结合血红蛋白电泳HbA2检测结果在产前筛查地中海贫血中的应用。方法：选取来我院常规产检的1680例孕妇进行血细胞分析，血红蛋白电泳及血清铁检测。按地贫筛查流程，经基因确诊为地中海贫血患者125例。结果：α地贫55例，β地贫60例，αβ复合型8例，静止型α地贫组与轻型α地贫组、轻型β地贫组和αβ复合组间MCV的差异有统计学意义(P<0.05)。结论：临床上检测MCV、MCH与HbA2对产前筛查地贫有较高价值，联合检测能更有效地筛查出地贫携带者。
목적：탐토혈세포분석중적평균홍세포체적(MCV)，평균홍세포혈홍단백량(MCH)，병결합혈홍단백전영HbA2검측결과재산전사사지중해빈혈중적응용。방법：선취래아원상규산검적1680례잉부진행혈세포분석，혈홍단백전영급혈청철검측。안지빈사사류정，경기인학진위지중해빈혈환자125례。결과：α지빈55례，β지빈60례，αβ복합형8례，정지형α지빈조여경형α지빈조、경형β지빈조화αβ복합조간MCV적차이유통계학의의(P<0.05)。결론：림상상검측MCV、MCH여HbA2대산전사사지빈유교고개치，연합검측능경유효지사사출지빈휴대자。
Objective:To investigate the mean corpuscular volume (MCV),mean corpuscular hemoglobin (MCH), and the combination of hemoglobin electrophoresis results of HbA2 testing for screening thalassemia.Methods:1680 cases of pregnant women were selected in our hospital,routine blood cell examination, hemoglobin electrophoresis and serum iron assay were collected. Finally, 125 cases diagnosed as thalassemia by PCR were enrolled.Results:55 cases diagnosed asαthalassemia, 60 cases with beta thalassemia, 8 cases with composite type.The MCV had a significant difference among lightαthalassemia group, staticαthalassemia group, static type of alpha group and beta-αthalassemia compound group (P<0.05).Conclusion:The clinical detection of MCV, MCH and HbA2 in prenatal women on screening thalassemia has a more high value, this method is worth popularizing in basic level hospital in China.