CAJ | 학술논문

目的：评价多西他赛(DOC)联合顺铂(DDP)治疗复发、转移晚期鼻咽癌的疗效及其不良反应。方法：诊断明确的转移、治疗后复发的晚期鼻咽癌且对PF方案耐药的患者21例；第1天静脉滴注多西他赛75mg/m2,顺铂30mg/m2第(1~3)天静滴,21天为一周期所有患者均治疗2周期,观察不良反应并评价化疗疗效。结果：CR 1例(4.76%),PR 13例(57.14%),SD 5例(23.81%),PD 2例(9.52%)。总有效率66.67%。最常见不良反应是反应骨髓抑制的Ⅲ～Ⅳ度粒细胞减少(76.2%)和Ⅱ～Ⅲ度血小板减少(47.6)。其余毒副反应则可以耐受。结论：DOC联合DDP对复发、转移晚期鼻咽癌的疗效肯定,患者多能耐受其不良反应,此化疗运用于临床可行,值得进一步研究应用
목적：평개다서타새(DOC)연합순박(DDP)치료복발、전이만기비인암적료효급기불량반응。방법：진단명학적전이、치료후복발적만기비인암차대PF방안내약적환자21례；제1천정맥적주다서타새75mg/m2,순박30mg/m2제(1~3)천정적,21천위일주기소유환자균치료2주기,관찰불량반응병평개화료료효。결과：CR 1례(4.76%),PR 13례(57.14%),SD 5례(23.81%),PD 2례(9.52%)。총유효솔66.67%。최상견불량반응시반응골수억제적Ⅲ～Ⅳ도립세포감소(76.2%)화Ⅱ～Ⅲ도혈소판감소(47.6)。기여독부반응칙가이내수。결론：DOC연합DDP대복발、전이만기비인암적료효긍정,환자다능내수기불량반응,차화료운용우림상가행,치득진일보연구응용
Objective:To evaluate docetaxel (DOC) combined with cisplatin (DDP) and its efficacy in treatment of recurrent, metastatic advanced nasopharyngeal carcinoma.Methods:Diagnosis of metastasis,21 cases of patients with advanced nasopharyngeal carcinoma recurrence and scheme of PF resistance after treatment method;first days of intravenous infusion of docetaxel and cisplatin 75mg/m2, 30mg/m2 days (1~3) intravenous drip, 21 days for a cycle of all patients were treated for 2 cycles,observe the adverse reaction and evaluation of treatment efficacy.Results:CR 1 cases (4.76%),PR 13 cases (57.14%),SD 5 cases (23.81%), 2 cases of PD (9.52%). The total efficiency of 66.67%.The most common adverse reaction is bone marrow suppression of grade 3-4 neutropenia(76.2%) and II~III thrombocytopenia(47.6).The toxic and side reaction can be tolerated. The curative effect of advanced nasopharyngeal carcinoma. Conclusion:DOC combined with DDP on recurrence, metastasis, patients can tolerate the adverse reaction of chemotherapy, which are applied to the clinical feasibility, worthy of further research and Application.