中国医药导刊
中國醫藥導刊
중국의약도간
CHINESE JOURNAL OF MEDICAL GUIDE
2013年
9期
1499-1500,1502
,共3页
2型糖尿病%急性脑梗塞%依达拉奉%银杏达莫%经颅多普勒(TCD)
2型糖尿病%急性腦梗塞%依達拉奉%銀杏達莫%經顱多普勒(TCD)
2형당뇨병%급성뇌경새%의체랍봉%은행체막%경로다보륵(TCD)
Type 2 diabetes%Acute cerebral infarction%Edaravone%Ginkgo leaf extract and dipyridamole%Transcranial Doppler(TCD)
目的：观察分析依达拉奉联合银杏达莫治疗2型糖尿病并发急性脑梗塞的临床疗效以及安全性。方法：将48例在48h内发病的糖尿病并发急性脑梗塞患者随机分成治疗组和对照组,两组均为24例患者。治疗组给予依达拉奉30mg+生理盐水100ml进行静脉滴注,每日2次,同时给予(银杏达莫30ml+生理盐水250ml)静脉滴注,每日1次,连用14d；对照组给予同等剂量,同疗程的银杏达莫,同时给予(胞二磷胆碱500mg+生理盐水)250ml静脉滴注。2组患者在进行治疗前及后14d时进行临床神经功能缺损程度评分及临床疗效评定、并通过TCD观察颅内血管平均血流速度(Vm)与阻力指数(RI)的变化和不良反应。结果：治疗组有效率(96)显著高于对照组(87)。两组患者治疗后神经功能评分均有明显改善,但治疗组明显优于对照组(P<0.05),经TCD观察比较48例患者治疗前后椎基底动脉血流速度以及改善脑部血流情况上,治疗组疗效明显优于对照组,P<0.05, P<0.001。两组均未见不良反应。结论：依达拉奉联合银杏达莫治疗2型糖尿病并发急性脑梗塞的临床效果更加明显且安全。
目的：觀察分析依達拉奉聯閤銀杏達莫治療2型糖尿病併髮急性腦梗塞的臨床療效以及安全性。方法：將48例在48h內髮病的糖尿病併髮急性腦梗塞患者隨機分成治療組和對照組,兩組均為24例患者。治療組給予依達拉奉30mg+生理鹽水100ml進行靜脈滴註,每日2次,同時給予(銀杏達莫30ml+生理鹽水250ml)靜脈滴註,每日1次,連用14d；對照組給予同等劑量,同療程的銀杏達莫,同時給予(胞二燐膽堿500mg+生理鹽水)250ml靜脈滴註。2組患者在進行治療前及後14d時進行臨床神經功能缺損程度評分及臨床療效評定、併通過TCD觀察顱內血管平均血流速度(Vm)與阻力指數(RI)的變化和不良反應。結果：治療組有效率(96)顯著高于對照組(87)。兩組患者治療後神經功能評分均有明顯改善,但治療組明顯優于對照組(P<0.05),經TCD觀察比較48例患者治療前後椎基底動脈血流速度以及改善腦部血流情況上,治療組療效明顯優于對照組,P<0.05, P<0.001。兩組均未見不良反應。結論：依達拉奉聯閤銀杏達莫治療2型糖尿病併髮急性腦梗塞的臨床效果更加明顯且安全。
목적：관찰분석의체랍봉연합은행체막치료2형당뇨병병발급성뇌경새적림상료효이급안전성。방법：장48례재48h내발병적당뇨병병발급성뇌경새환자수궤분성치료조화대조조,량조균위24례환자。치료조급여의체랍봉30mg+생리염수100ml진행정맥적주,매일2차,동시급여(은행체막30ml+생리염수250ml)정맥적주,매일1차,련용14d；대조조급여동등제량,동료정적은행체막,동시급여(포이린담감500mg+생리염수)250ml정맥적주。2조환자재진행치료전급후14d시진행림상신경공능결손정도평분급림상료효평정、병통과TCD관찰로내혈관평균혈류속도(Vm)여조력지수(RI)적변화화불량반응。결과：치료조유효솔(96)현저고우대조조(87)。량조환자치료후신경공능평분균유명현개선,단치료조명현우우대조조(P<0.05),경TCD관찰비교48례환자치료전후추기저동맥혈류속도이급개선뇌부혈류정황상,치료조료효명현우우대조조,P<0.05, P<0.001。량조균미견불량반응。결론：의체랍봉연합은행체막치료2형당뇨병병발급성뇌경새적림상효과경가명현차안전。
Objective:To observe and analysis the clinical efficacy and safety of edaravone combined with ginkgo leaf extract and dipyridamole in the treatment of type 2 diabetes complicated with acute cerebral infarction. Methods:48 cases in 48h patients of diabetes mellitus complicated with acute cerebral infarction were randomly divided into treatment group and control group, two groups of 24 patients. Treatment group were given edaravone 30mg+100ml normal saline for intravenous drip, 2 times a day, while giving (Ginkgo leaf extract and dipyridamole 30ml+physiological saline 250ml) intravenous infusion, 1 times daily, for 14d;control group received the same dose, the same course of ginkgo leaf extract and dipyridamole, while giving (cell two choline 500mg+saline) 250ml intravenous drip note. 2 groups of patients with clinical neurological impairment score and the clinical curative effect evaluation, in the treatment before and after 14d TCD was used to observe the mean blood flow velocity of intracranial vascular (Vm) and resistance index (RI) changes and adverse reactions.Results:The effective rate of the treatment group (96) was significantly higher than that of the control group (87). The nerve function score was significantly improved after treatment in two groups, but the treatment group was significantly better than the control group (P<0.05), the TCD were observed in 48 patients before and after treatment of vertebral basilar artery blood flow velocity and improve brain blood flow, significantly better than the control group, the curative effect of treatment group P<0.05, P<0.001. The two groups were no adverse reaction.Conclusion:The clinical effect of edaravone combined with ginkgo leaf extract and dipyridamole in treatment of type 2 diabetes mellitus complicated with acute cerebral infarction is more obvious and safe.
