CAJ | 학술논문

目的：检测叶酸治疗前后儿童过敏性紫癜( HSP )患者血清中同型半胱氨酸( HCY )与CD62E的水平。方法：采用循环酶法和酶联免疫吸附试验检测40例儿童HSP 患者(根据是否伴有肾脏损害分为A、B组)与31名健康对照者( C组)外周血清HCY与CD62E水平。结果： A、B、C组外周血清HCY水平分别为4.39±1.35μmol/L、3.58±1.23μmol/L和3.43±1.37μmol/L；CD62E的水平分别为14.59±4.52 ng/mL、12.34±3.48 ng/mL 和10.37±3.16 ng/mL。 HSP患者血清HCY与CD62E水平较健康对照者为高( P<0.05)，伴有肾脏损害的HSP患者与不伴有肾脏损害组和健康对照者相比，外周血清HCY与CD62E差异有统计学意义( P<0.01)。结论：儿童HSP患者血清中HCY和CD62E异常表达可能通过血管内皮的损伤参与了HSP的发生机制。
목적：검측협산치료전후인동과민성자전( HSP )환자혈청중동형반광안산( HCY )여CD62E적수평。방법：채용순배매법화매련면역흡부시험검측40례인동HSP 환자(근거시부반유신장손해분위A、B조)여31명건강대조자( C조)외주혈청HCY여CD62E수평。결과： A、B、C조외주혈청HCY수평분별위4.39±1.35μmol/L、3.58±1.23μmol/L화3.43±1.37μmol/L；CD62E적수평분별위14.59±4.52 ng/mL、12.34±3.48 ng/mL 화10.37±3.16 ng/mL。 HSP환자혈청HCY여CD62E수평교건강대조자위고( P<0.05)，반유신장손해적HSP환자여불반유신장손해조화건강대조자상비，외주혈청HCY여CD62E차이유통계학의의( P<0.01)。결론：인동HSP환자혈청중HCY화CD62E이상표체가능통과혈관내피적손상삼여료HSP적발생궤제。
Objective: To determine the effects of folic acid on the serum level of homocysteine (HCY) and CD62E in children patients with Henoch-Schonlein purpura (HSP). Methods:Forty children with HSP,including 22 patients with renal involvement ( group A) and 18 patients without renal involvement ( group B),and 31 normal controls ( group C) were recruited into the study. The serum levels of HCY and CD62E were detected by cycle enzyme and ELISA, separately. Results: The serum levels of HCY in group A, B and C were 4.39±1.35 μmol/L,3.58±1.23μmol/L,and 3.43±1.37μmol/L,respectively,and the serum levels of CD62E in group A,B and C were 14.59±4.52 ng/mL,12.34±3.48 ng/mL and 10.37±3.16 ng/mL,respectively. The serum levels of HCY and CD62E in patients with HSP were significantly higher than those in controls ( P<0.05) . Besides, the serum levels of HCY and CD62E in HSP with renal involvement were significantly higher than those in normal controls (P<0.01). Conclusions: The increased serum level of HCY and CD62E in pediatric patients with HSP may be correlated to the pathogenesis of HSP via vascular endothelium injury.