CAJ | 학술논문

目的：探索重复经颅磁刺激（rTMS）联合西酞普兰治疗抑郁症的疗效和安全性。方法：将符合 CCMD-3诊断标准的60例抑郁症患者随机分为联用组30例和对照组30例。两组均给予西酞普兰40mg/d（最高剂量），疗程4周。联用组在服药基础上联合重复经颅磁刺激治疗，以30％强度刺激患者颅脑左额叶背外侧，频率为10Hz，共治疗4个疗程。治疗前和治疗后第1、2、4周末采用HAMD-17量表评定抑郁症状，采用 TESS量表评定不良反应。结果：两组HAMD-17评分在治疗2周末与治疗前比较差异均有统计学意义（P＜0．05或P＜0．01），联用组在治疗第1周末即具有明显疗效（P＜0．01）。联用组有效率高于对照组（P＜0．05）。两组均未观察到明显的不良反应。结论：重复经颅磁刺激联合西酞普兰治疗抑郁症疗效显著，具有良好的安全性。
목적：탐색중복경로자자격（rTMS）연합서태보란치료억욱증적료효화안전성。방법：장부합 CCMD-3진단표준적60례억욱증환자수궤분위련용조30례화대조조30례。량조균급여서태보란40mg/d（최고제량），료정4주。련용조재복약기출상연합중복경로자자격치료，이30％강도자격환자로뇌좌액협배외측，빈솔위10Hz，공치료4개료정。치료전화치료후제1、2、4주말채용HAMD-17량표평정억욱증상，채용 TESS량표평정불량반응。결과：량조HAMD-17평분재치료2주말여치료전비교차이균유통계학의의（P＜0．05혹P＜0．01），련용조재치료제1주말즉구유명현료효（P＜0．01）。련용조유효솔고우대조조（P＜0．05）。량조균미관찰도명현적불량반응。결론：중복경로자자격연합서태보란치료억욱증료효현저，구유량호적안전성。
Objective To explore the therapeutic effect and safety of treating depression by repetitive transcranial magnetic stimulation combined with Citalopram.Methods Sixty cases of depressive participates were randomly divided into combination group (30 cases) and control group (30 cases).Two groups were given Citalopram 40mg/d for four weeks.On the same time,the combination group applied repetitive transcranial magnetic stimulation treatment .HAMD-17 rating scale were used to evaluate depression symptoms before and after treatment with 1,2,4 weekend.TESS rating scale were used to evaluate side effects. Results Sixty patients were completed the treatment.There were significantly different in HAMD-17 scores between the treatment of the 2 weeks and before treat-ment (P<0.05 or P<0.01).Combination group showed significant effect on the first weekend (P<0.01).The effectiveness in combination group was higher than control groups (P<0.05).The significant side effects were not observed in the two groups.Conclusion Repetitive transcranial magnetic stimulation com-bined with Citalopram has significantly effect,safety,and can improve therapeutic effect in the treatment of depression.