CAJ | 학술논문

目的了解苏州大学附属第三医院血管内导管相关性血流感染（CRBSI）的病原菌分布及细菌耐药情况，为临床提供可靠的诊疗依据。方法对确诊为CRBSI的49例患者回顾性分析其病原菌分布及细菌耐药情况。结果49例患者共检出49株病原菌，其中革兰阳性菌占61．22％（30/49），以金黄色葡萄球菌和凝固酶阴性葡萄球菌为主；革兰阴性菌占22．45％（11/49），以肠杆菌科和不动杆菌属为主；真菌占16．33％（8/49），均为假丝酵母菌。革兰阳性菌对万古霉素、利奈唑胺的耐药率均为0．00％，对喹奴普丁/达福普丁的耐药率为3．45％；革兰阴性菌对头孢哌酮/舒巴坦和亚胺培南的耐药率分别为9．09％、18．18％；未发现对5-氟胞嘧啶和两性霉素耐药的真菌。结论了解CRBSI感染和药敏有助于预防和指导CRBSI的治疗。
목적료해소주대학부속제삼의원혈관내도관상관성혈류감염（CRBSI）적병원균분포급세균내약정황，위림상제공가고적진료의거。방법대학진위CRBSI적49례환자회고성분석기병원균분포급세균내약정황。결과49례환자공검출49주병원균，기중혁란양성균점61．22％（30/49），이금황색포도구균화응고매음성포도구균위주；혁란음성균점22．45％（11/49），이장간균과화불동간균속위주；진균점16．33％（8/49），균위가사효모균。혁란양성균대만고매소、리내서알적내약솔균위0．00％，대규노보정/체복보정적내약솔위3．45％；혁란음성균대두포고동/서파탄화아알배남적내약솔분별위9．09％、18．18％；미발현대5-불포밀정화량성매소내약적진균。결론료해CRBSI감염화약민유조우예방화지도CRBSI적치료。
Objective To understand the distribution and drug resistance of the pathogens causing in intravas-cular catheter-related bloodstream infections (CRBSI) ,and provide reliable basis for clinical diagnosis and treatment . Methods A retrospective analysis of the distribution of pathogens and drug resistance in 49 patients with CRBSI di-agnosed .Results A total of 49 patients were detected in 49 strains of pathogens ,including Gram-positive bacteria ac-counted for 61 .22% (30/49) ,mainly in Staphylococcus aureus and coagulase-negative staphylococci ;Gram-negative bacteria accounted for 22 .45% (11/49 ) ,mainly in Enterobacteriaceae and Acinetobacter ;Fungi accounted for 16 .33% (8/49 ) ,were Candida .Gram-positive bacteria to Vancomycin ,Linezolid resistance rate was 0 .00% ,to Quinupristin/Dalfopristin resistance rate was 3 .45% ;Gram-negative bacteria to Cefoperazone /Shubatan and Imi-penem resistance rate was 9 .09% ,18 .18% respectively ;Not found in fungi ,which was resistant to 5-fluorocytosine and amphotericin B .Conclusion To understand the distribution and drug resistance of pathogens causing in intra-vascular CRBSI ,which can contribute to the prevention and treatment of CRBSI .