CAJ | 학술논문

目的了解南方医科大学南方医院血液科患者分离病原菌种类及耐药性，为合理使用抗菌药物提供依据。方法细菌鉴定和药敏试验采用BD Phoenix100仪器。念珠菌利用显色平板鉴定和K-B法进行药敏试验。数据分析用WHONET5．6软件。结果血液科患者分离病原菌中最常见的为大肠埃希菌、肺炎克雷伯菌、铜绿假单胞菌、屎肠球菌和粪肠球菌。大肠埃希菌和肺炎克雷伯菌产超广谱β-内酰胺酶比例分别为56．1％和33．6％。金黄色葡萄球菌、溶血葡萄球菌和表皮葡萄球菌甲氧西林耐药率分别为20．0％、88．0％和91．5％。革兰阴性杆菌中耐药率较低的为亚胺培南、美罗培南、阿米卡星、头孢哌酮/舒巴坦、哌拉西林/他唑巴坦。革兰阳性球菌对替考拉宁和利奈唑胺的敏感率均为100．0％，葡萄球菌属对万古霉素的敏感率也为100．0％。念珠菌对临床常用抗菌药物的耐药率均低于7．0％。结论南方医科大学南方医院血液科患者分离病原菌耐药率较高，应加强抗菌药物的合理使用，以降低耐药率。
목적료해남방의과대학남방의원혈액과환자분리병원균충류급내약성，위합리사용항균약물제공의거。방법세균감정화약민시험채용BD Phoenix100의기。념주균이용현색평판감정화K-B법진행약민시험。수거분석용WHONET5．6연건。결과혈액과환자분리병원균중최상견적위대장애희균、폐염극뢰백균、동록가단포균、시장구균화분장구균。대장애희균화폐염극뢰백균산초엄보β-내선알매비례분별위56．1％화33．6％。금황색포도구균、용혈포도구균화표피포도구균갑양서림내약솔분별위20．0％、88．0％화91．5％。혁란음성간균중내약솔교저적위아알배남、미라배남、아미잡성、두포고동/서파탄、고랍서림/타서파탄。혁란양성구균대체고랍저화리내서알적민감솔균위100．0％，포도구균속대만고매소적민감솔야위100．0％。념주균대림상상용항균약물적내약솔균저우7．0％。결론남방의과대학남방의원혈액과환자분리병원균내약솔교고，응가강항균약물적합리사용，이강저내약솔。
Objective To investigate distribution and drug resistance of pathogen isolated in department of he-matology ,NanFang Hospital ,Southern Medical University for using antibacterials reasonably .Methods Most bacte-ria isolates were identified with BD Phoenix100 .Candida isolates were identified by color display plate and drug sensi-tive test by K-B method .WHONET5 .6 was applied for analysis .Results The common pathogen isolated in depart-ment of hematology were Escherichia coli ,Klebsiella pneumoniae ,Pseudomonas aeruginosa ,Enterococcus faecium , Enterococcus faecalis .The incidences of Escherichia coli and Klebsiella pneumoniae isolates producing extended spec-trum beta-lactamase were 56 .1% and 33 .6% respectively .Drug resistance rate of methicillin-resistant Staphylococ-cus aureus ,Staphylococcus haemolyticus and Staphylococcus epidermidis were 20 .0% ,88 .0% and 91 .5% respective-ly .In gram negative bacillus ,lower resistance rate of antimicrobials were Imipenem ,Meropenem ,Amikacin ,Cefopera-zone/Sulbactam ,and Piperacillin/Tazobactam .In gram positive coccus ,sensitivity of Teicoplanin and Linezolid were 100 .0% .In Staphylococcus ,sensitivity of Vancomycin was 100 .0% .Candida drug resistance rate was less than 7 .0% to clinical commonly used antimicrobials .Conclusion Drug resistance rate of pathogen isolated in department of hematolog in the hospital were high ,it is important to enforce the rational use of antimicrobials for reducing the drug resistace rate .