CAJ | 학술논문

目的比较培门冬酶与左旋门冬酰胺酶在儿童急性淋巴细胞白血病诱导化疗中的毒副作用和临床疗效。方法将2010年10月-2012年1月我院100例儿童急性淋巴细胞白血病患者随机分成两组各50例，对照组使用培门冬酶治疗，观察组采用左旋门冬酰胺酶治疗，治疗结束后比较两组患者的毒副作用和临床疗效。结果两组完全缓解率、总有效率、不良反应情况无统计学差异(P>0.05)；观察组用药次数和住院时间明显多于对照组，差异有统计学意义(P<0.05)。结论培门冬酶与左旋门冬酰胺酶诱导化疗儿童急性淋巴细胞白血病均有较好疗效，但培门冬酶用药次数和住院时间明显缩短，需在临床应用时加以注意。
목적비교배문동매여좌선문동선알매재인동급성림파세포백혈병유도화료중적독부작용화림상료효。방법장2010년10월-2012년1월아원100례인동급성림파세포백혈병환자수궤분성량조각50례，대조조사용배문동매치료，관찰조채용좌선문동선알매치료，치료결속후비교량조환자적독부작용화림상료효。결과량조완전완해솔、총유효솔、불량반응정황무통계학차이(P>0.05)；관찰조용약차수화주원시간명현다우대조조，차이유통계학의의(P<0.05)。결론배문동매여좌선문동선알매유도화료인동급성림파세포백혈병균유교호료효，단배문동매용약차수화주원시간명현축단，수재림상응용시가이주의。
Objective To compare The side effects and clinical efficacy of Pegaspargase and L-asparaginase in the treatment of childhood acute lymphoblastic leukemia, and provide a reference for the clinical treatment of children with acute lymphoblastic leukemia. Methods During October 2010-2012 in January during our hospital, 100 cases of childhood acute lymphoblastic leukemia patients were randomly divided into control group and observation group, 50 cases in each group of patients, the control group patients were treated with pegaspargase, and the observation group were treated with L-asparaginase, after treatment, to compare the clinical efficacy and side effects. Results The differences in the complete remission rate, the total effective rate, and the adverse reactions of two groups of patients were no significant(P>0.05). The number of drugs and hospitalization time of the observation group of patients were significantly more than the control group of patients, the differences of two groups of patients were statistically significant(P<0.05). Conclusion In children with acute lymphoblastic leukemia induction chemotherapy, pegaspargase and L-asparaginase has better clinical efficacy and incidence of adverse reactions undifferentiated, but the number of patients treated with pegaspargase medication and hospitalization time was significantly shorter.