CAJ | 학술논문

目的探讨腮腺硬化性多囊性腺病(SPA)的临床病理特征,以提高对SPA的临床和病理改变的认识.方法对2例腮腺SPA的临床资料和病理组织学形态特征进行回顾性分析,采用组织化学染色和免疫组织化学染色初步探讨SPA的形态和免疫表型特点,并参考相关文献对其进行总结.结果腮腺SPA患者的临床表现主要为腮腺无痛性结节状肿块.其组织学表现主要是在玻璃样变硬化胶原组织背景中可见囊性扩张的导管和腺泡,导管中可见大汗腺化生,局灶导管上皮增生伴结构不良.腮腺SPA的免疫组化染色calponin和SMA染色结果可见导管周围有一层肌上皮细胞.结论腮腺SPA发病率低,目前对病因、发病机制和病程均不明确,如在导管上皮发现显著的非典型现象,术后应对患者加强随访.
목적 탐토시선경화성다낭성선병(SPA)적림상병리특정,이제고대SPA적림상화병리개변적인식.방법 대2례시선SPA적림상자료화병리조직학형태특정진행회고성분석,채용조직화학염색화면역조직화학염색초보탐토SPA적형태화면역표형특점,병삼고상관문헌대기진행총결.결과 시선SPA환자적림상표현주요위시선무통성결절상종괴.기조직학표현주요시재파리양변경화효원조직배경중가견낭성확장적도관화선포,도관중가견대한선화생,국조도관상피증생반결구불량.시선SPA적면역조화염색calponin화SMA염색결과가견도관주위유일층기상피세포.결론 시선SPA발병솔저,목전대병인、발병궤제화병정균불명학,여재도관상피발현현저적비전형현상,술후응대환자가강수방.
Objective To investigate the clinicopathologic features of sclerosing polycystic adenosis(SPA)of salivary gland.Methods The clinical and pathologic profiles of 2 SPA cases were evaluated.Immunohistochemical study was performed on fixed tissues.The biologic behavior was analyzed with follow-up data.Results The main clinical manifestation of patients was parotid painless nodules.Histological features were embedded cystic dilatation of ducts and alveoli as hyaline sclerosis collagen tissue background,catheter see apocrine metaplasia,focal areas of ductal epithelial hyperplasia and dysplasia.Immunohistochemical staining for calponin and SMA staining showed that the catheter had a layer of myoepithelial cells.Conclusion Sclerosing polycystic sialadenopathy of parotid is a rare disease,the cause and course of the disease are not very clear,but the literature reports are atypical ductal epithelial remarkable phenomenon,thus strengthen the follow-up to patients.