中国医药
中國醫藥
중국의약
CHINA MEDICINE
2014年
7期
986-988
,共3页
牛智领%牛好敏%刘远洪%郝静%葛晓航%闫斌
牛智領%牛好敏%劉遠洪%郝靜%葛曉航%閆斌
우지령%우호민%류원홍%학정%갈효항%염빈
缺血性脑小血管病%天智颗粒%轻度认知障碍%蒙特利尔认知功能评估量表
缺血性腦小血管病%天智顆粒%輕度認知障礙%矇特利爾認知功能評估量錶
결혈성뇌소혈관병%천지과립%경도인지장애%몽특리이인지공능평고량표
Ischemic cerebrovascular small vessel disease%Tianzhi granule%Mild cognitive impairment%Montreal cognitive assessment
目的 评价天智颗粒对缺血性脑小血管病所致轻度认知障碍的治疗作用,为早期干预提供临床依据.方法 将濮阳市人民医院神经内科门诊及住院的缺血性脑小血管病所致轻度认知障碍患者100例完全随机分为观察组(50例)、对照组(50例).2组患者均给予对症治疗,观察组在此基础上给予天智颗粒5g/次,3次/d口服,共12周,分别测治疗前后蒙特利尔认知评估量表评分(MoCA).结果 观察组治疗后与治疗前及对照组治疗后相比,在视空间/执行功能[(4.1±0.2)分比(2.6±0.2)、(2.7±0.3)分]、注意力[(5.1±1.6)分比(4.4±1.8)、(4.7±1.5)分]、语言[(2.4±0.8)分比(1.8±0.5)、(1.6±0.3)分]、抽象能力[(1.5±0.5)分比(1.4±0.5)、(1.2±0.2)分]、延迟回忆[(3.0±0.8)分比(1.1±0.5)、(1.1±0.3)分]及总分[(23.4±5.0)分比(18.7±4.9)、(18.5±4.4)分]方面差异有统计学意义(均P＜0.05).结论 天智颗粒对缺血性小血管病所致轻度认知障碍有明显治疗作用.
目的 評價天智顆粒對缺血性腦小血管病所緻輕度認知障礙的治療作用,為早期榦預提供臨床依據.方法 將濮暘市人民醫院神經內科門診及住院的缺血性腦小血管病所緻輕度認知障礙患者100例完全隨機分為觀察組(50例)、對照組(50例).2組患者均給予對癥治療,觀察組在此基礎上給予天智顆粒5g/次,3次/d口服,共12週,分彆測治療前後矇特利爾認知評估量錶評分(MoCA).結果 觀察組治療後與治療前及對照組治療後相比,在視空間/執行功能[(4.1±0.2)分比(2.6±0.2)、(2.7±0.3)分]、註意力[(5.1±1.6)分比(4.4±1.8)、(4.7±1.5)分]、語言[(2.4±0.8)分比(1.8±0.5)、(1.6±0.3)分]、抽象能力[(1.5±0.5)分比(1.4±0.5)、(1.2±0.2)分]、延遲迴憶[(3.0±0.8)分比(1.1±0.5)、(1.1±0.3)分]及總分[(23.4±5.0)分比(18.7±4.9)、(18.5±4.4)分]方麵差異有統計學意義(均P＜0.05).結論 天智顆粒對缺血性小血管病所緻輕度認知障礙有明顯治療作用.
목적 평개천지과립대결혈성뇌소혈관병소치경도인지장애적치료작용,위조기간예제공림상의거.방법 장복양시인민의원신경내과문진급주원적결혈성뇌소혈관병소치경도인지장애환자100례완전수궤분위관찰조(50례)、대조조(50례).2조환자균급여대증치료,관찰조재차기출상급여천지과립5g/차,3차/d구복,공12주,분별측치료전후몽특리이인지평고량표평분(MoCA).결과 관찰조치료후여치료전급대조조치료후상비,재시공간/집행공능[(4.1±0.2)분비(2.6±0.2)、(2.7±0.3)분]、주의력[(5.1±1.6)분비(4.4±1.8)、(4.7±1.5)분]、어언[(2.4±0.8)분비(1.8±0.5)、(1.6±0.3)분]、추상능력[(1.5±0.5)분비(1.4±0.5)、(1.2±0.2)분]、연지회억[(3.0±0.8)분비(1.1±0.5)、(1.1±0.3)분]급총분[(23.4±5.0)분비(18.7±4.9)、(18.5±4.4)분]방면차이유통계학의의(균P＜0.05).결론 천지과립대결혈성소혈관병소치경도인지장애유명현치료작용.
Objective To evaluate the effect of Tianzhi particles on patients with mild cognitive impairment caused by ischemic small vessel disease.Methods Totally 100 cases caused by ischemic small vessel disease were randomly divided into 2 groups:observation group(50 cases) and control group (50 cases).The observation group was given Tianzhi particles for 12 weeks and the Montreal Cognitive Assessment Scale was used.Results Compared with the observation group before and after treatment and the control group after treatment,the visual space/executive function[(4.1 ±0.2) vs(2.6 ±0.2),(2.7 ±0.3)],attention[(5.1 ± 1.6) vs (4.4 ±1.8),(4.7±1.5)],language[(2.4±0.8) vs (1.8 ±0.5),(1.6±0.3)],abstraction[(1.5 ±0.5) vs (1.4±0.5),(1.2±0.2)],delayed recall[(3.0±0.8) vs (1.1 ±0.5)、(1.1 ±0.3)]and the total score [(23 ±5) vs (19 ±4),(19 ±4)] of there was significantly different(P ＜0.05).Conclusion Tianzhi granule is good for patients with mild cognitive impairment caused by ischemic small vessel disease.
